PMID- 26413910
OWN - NLM
STAT- MEDLINE
DCOM- 20180110
LR  - 20180628
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 33
IP  - 9
DP  - 2016 May 1
TI  - Neuroimaging Biomarkers of a History of Concussion Observed in Asymptomatic Young 
      Athletes.
PG  - 803-10
LID - 10.1089/neu.2014.3721 [doi]
AB  - Participation in contact sports places athletes at elevated risk for repeated 
      head injuries and is associated with negative mental health outcomes later in 
      life. The current study identified changes observable on neuroimaging that 
      persisted beyond the apparent resolution of acute symptoms of concussion. Sixteen 
      young adult ice hockey players with a remote history of concussion but no 
      subjective complaints were compared against 13 of their teammates with no history 
      of concussion. Participants completed a detailed phenotypic assessment and a 
      neuroimaging battery including diffusion kurtosis imaging and resting-state 
      functional magnetic resonance imaging. Athletes with a history of concussion 
      performed no differently from those without on phenotypic assessment, but showed 
      significantly elevated fractional anisotropy (FA) in the left genu and anterior 
      corona radiata relative to those without. Post hoc analyses revealed that 
      elevated FA was associated with increased microstructural complexity 
      perpendicular to the primary axon (radial kurtosis). Athletes with concussion 
      history also showed significant differences in the organization of the default 
      mode network (DMN) characterized by stronger temporal coherence in posterior DMN, 
      decreased temporal coherence in anterior DMN, and increased functional 
      connectivity outside the DMN. In the absence of deficits on detailed phenotypic 
      assessment, athletes with a history of concussion displayed changes to the 
      microstructural architecture of the cerebral white matter and to the functional 
      connectivity of the brain at rest. Some of these changes are consistent with 
      those previously associated with persisting deficits and complaints, but we also 
      report novel, complementary changes that possibly represent compensatory 
      mechanisms.
FAU - Orr, Catherine A
AU  - Orr CA
AD  - 1 Vermont Center for Children, Youth, and Families, University of Vermont , 
      Burlington, Vermont.
FAU - Albaugh, Matthew D
AU  - Albaugh MD
AD  - 1 Vermont Center for Children, Youth, and Families, University of Vermont , 
      Burlington, Vermont.
FAU - Watts, Richard
AU  - Watts R
AD  - 2 Department of Radiology, University of Vermont , Burlington, Vermont.
AD  - 6 MRI Center for Biomedical Imaging, University of Vermont , Burlington, Vermont.
FAU - Garavan, Hugh
AU  - Garavan H
AD  - 3 Department of Psychiatry, University of Vermont , Burlington, Vermont.
AD  - 4 Department of Psychology, University of Vermont , Burlington, Vermont.
FAU - Andrews, Trevor
AU  - Andrews T
AD  - 2 Department of Radiology, University of Vermont , Burlington, Vermont.
AD  - 5 Philips Healthcare , Cleveland, Ohio.
AD  - 6 MRI Center for Biomedical Imaging, University of Vermont , Burlington, Vermont.
FAU - Nickerson, Joshua P
AU  - Nickerson JP
AD  - 2 Department of Radiology, University of Vermont , Burlington, Vermont.
AD  - 6 MRI Center for Biomedical Imaging, University of Vermont , Burlington, Vermont.
FAU - Gonyea, Jay
AU  - Gonyea J
AD  - 6 MRI Center for Biomedical Imaging, University of Vermont , Burlington, Vermont.
FAU - Hipko, Scott
AU  - Hipko S
AD  - 6 MRI Center for Biomedical Imaging, University of Vermont , Burlington, Vermont.
FAU - Zweber, Cole
AU  - Zweber C
AD  - 1 Vermont Center for Children, Youth, and Families, University of Vermont , 
      Burlington, Vermont.
FAU - Logan, Katherine
AU  - Logan K
AD  - 1 Vermont Center for Children, Youth, and Families, University of Vermont , 
      Burlington, Vermont.
FAU - Hudziak, James J
AU  - Hudziak JJ
AD  - 1 Vermont Center for Children, Youth, and Families, University of Vermont , 
      Burlington, Vermont.
AD  - 7 Erasmus University, Sophia Children's Hospital , Rotterdam, The Netherlands .
AD  - 8 Department of Child Psychiatry, Washington University , St. Louis, Missouri.
LA  - eng
PT  - Journal Article
DEP - 20151023
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Anisotropy
MH  - *Athletes
MH  - Biomarkers/metabolism
MH  - Brain Concussion/*diagnostic imaging/*metabolism
MH  - Diffusion Tensor Imaging/*methods
MH  - Hockey/*injuries
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Young Adult
OTO - NOTNLM
OT  - cognitive function
OT  - head trauma, MRI
OT  - neuroplasticity
EDAT- 2015/09/29 06:00
MHDA- 2018/01/11 06:00
CRDT- 2015/09/29 06:00
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2018/01/11 06:00 [medline]
AID - 10.1089/neu.2014.3721 [doi]
PST - ppublish
SO  - J Neurotrauma. 2016 May 1;33(9):803-10. doi: 10.1089/neu.2014.3721. Epub 2015 Oct 
      23.