PMID- 26414151
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20160125
IS  - 1097-685X (Electronic)
IS  - 0022-5223 (Linking)
VI  - 151
IP  - 2
DP  - 2016 Feb
TI  - Human leukocyte antigen mismatching and survival after lung transplantation in 
      adult and pediatric patients with cystic fibrosis.
PG  - 549-57.e1
LID - S0022-5223(15)01469-5 [pii]
LID - 10.1016/j.jtcvs.2015.08.022 [doi]
AB  - INTRODUCTION: The influence of human leukocyte antigen (HLA) mismatching on 
      survival in adult and pediatric patients with cystic fibrosis (CF) after lung 
      transplantation (LTx) is unknown. METHODS: The United Network for Organ Sharing 
      database was queried from 1987 to 2013 to determine the influence of HLA 
      mismatching on survival in adult and pediatric CF LTx recipients by assessing the 
      association of HLA mismatching with survival in first-time adult (aged >/= 18 
      years) and pediatric (aged <18 years) recipients. RESULTS: Of 3149 adult and 489 
      pediatric patients with CF, 3145 and 489 were used for univariate Cox analysis, 
      2687 and 363 for Kaplan-Meier survival analysis, and 2073 and 257 for 
      multivariate Cox analysis, respectively. Univariate analyses in adult and 
      pediatric patients with CF demonstrated conflicting associations between HLA 
      mismatching and survival (adult hazard ratio [HR], 1.0; 95% confidence interval 
      [CI], 0.97-1.1; P = .45 vs pediatric HR, 0.87; 95% CI, 0.77-0.99; P = .032). 
      Multivariate Cox models including both pediatric and adult patients confirmed 
      that HLA mismatching had an initially protective effect at young ages (HR, 0.85; 
      95% CI, 0.73-0.99; P = .044) and that this protective effect diminished at older 
      ages and was no longer associated with survival at P < .05 beyond age 10 years. 
      CONCLUSIONS: HLA mismatching has significantly different implications for 
      survival after LTx in adult compared with pediatric patients with CF.
CI  - Copyright (c) 2016 The American Association for Thoracic Surgery. Published by 
      Elsevier Inc. All rights reserved.
FAU - Hayes, Don Jr
AU  - Hayes D Jr
AD  - Department of Pediatrics, The Ohio State University College of Medicine, 
      Columbus, Ohio; Department of Internal Medicine, The Ohio State University 
      College of Medicine, Columbus, Ohio; Section of Pulmonary Medicine, Nationwide 
      Children's Hospital, Columbus, Ohio. Electronic address: hayes.705@osu.edu.
FAU - Auletta, Jeffery J
AU  - Auletta JJ
AD  - Department of Pediatrics, The Ohio State University College of Medicine, 
      Columbus, Ohio; Host Defense Program, Nationwide Children's Hospital, Columbus, 
      Ohio; Section of Hematology/Oncology and Bone Marrow Transplantation, Nationwide 
      Children's Hospital, Columbus, Ohio; Section of Infectious Diseases, Nationwide 
      Children's Hospital, Columbus, Ohio.
FAU - Whitson, Bryan A
AU  - Whitson BA
AD  - Department of Surgery, The Ohio State University College of Medicine, Columbus, 
      Ohio.
FAU - Black, Sylvester M
AU  - Black SM
AD  - Department of Surgery, The Ohio State University College of Medicine, Columbus, 
      Ohio.
FAU - Kirkby, Stephen
AU  - Kirkby S
AD  - Department of Pediatrics, The Ohio State University College of Medicine, 
      Columbus, Ohio; Department of Internal Medicine, The Ohio State University 
      College of Medicine, Columbus, Ohio; Section of Pulmonary Medicine, Nationwide 
      Children's Hospital, Columbus, Ohio.
FAU - Tobias, Joseph D
AU  - Tobias JD
AD  - Department of Anesthesiology, The Ohio State University College of Medicine, 
      Columbus, Ohio; Department of Anesthesiology and Pain Medicine, Nationwide 
      Children's Hospital, Columbus, Ohio.
FAU - Mansour, Heidi M
AU  - Mansour HM
AD  - Skaggs Pharmaceutical Sciences Center, The University of Arizona College of 
      Pharmacy, Tucson, Ariz.
LA  - eng
PT  - Journal Article
DEP - 20150813
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
RN  - 0 (HLA Antigens)
SB  - IM
CIN - J Thorac Cardiovasc Surg. 2016 Feb;151(2):558-9. PMID: 26412320
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - Cystic Fibrosis/diagnosis/mortality/*surgery
MH  - *Graft Survival
MH  - *HLA Antigens
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Lung Transplantation/adverse effects/mortality
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Tissue and Organ Procurement
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - cystic fibrosis
OT  - human leukocyte antigen mismatch
OT  - lung transplantation
OT  - survival
EDAT- 2015/09/29 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/09/29 06:00
PHST- 2015/02/26 00:00 [received]
PHST- 2015/08/03 00:00 [revised]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - S0022-5223(15)01469-5 [pii]
AID - 10.1016/j.jtcvs.2015.08.022 [doi]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 2016 Feb;151(2):549-57.e1. doi: 
      10.1016/j.jtcvs.2015.08.022. Epub 2015 Aug 13.