PMID- 26414795
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20240325
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Print)
IS  - 0897-7151 (Linking)
VI  - 33
IP  - 12
DP  - 2016 Jun 15
TI  - Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes 
      in a Severe Model of Spinal Cord Injury.
PG  - 1103-14
LID - 10.1089/neu.2015.4009 [doi]
AB  - Bone marrow stromal cells (BMSCs) have been reported to exert potential 
      neuroprotective properties in models of neurotrauma, although precise mechanisms 
      underlying their benefits are poorly understood. Despite this lack of knowledge, 
      several clinical trials have been initiated using these cells. To determine 
      whether local mechanisms mediate BMSC neuroprotective actions, we grafted 
      allogeneic BMSCs to sites of severe, compressive spinal cord injury (SCI) in 
      Sprague-Dawley rats. Cells were administered 48 h after the original injury. 
      Additional animals received allogeneic MSCs that were genetically modified to 
      secrete brain-derived neurotrophic factor (BDNF) to further determine whether a 
      locally administered neurotrophic factor provides or extends neuroprotection. 
      When assessed 2 months post-injury in a clinically relevant model of severe SCI, 
      BMSC grafts with or without BDNF secretion failed to improve motor outcomes. 
      Thus, allogeneic grafts of BMSCs do not appear to act through local mechanisms, 
      and future clinical trials that acutely deliver BMSCs to actual sites of injury 
      within days are unlikely to be beneficial. Additional studies should address 
      whether systemic administration of BMSCs alter outcomes from neurotrauma.
FAU - Brock, John H
AU  - Brock JH
AD  - 1 Department of Neurosciences, University of California , San Diego, La Jolla, 
      California.
AD  - 2 Veterans Administration San Diego Healthcare System , La Jolla, California.
FAU - Graham, Lori
AU  - Graham L
AD  - 1 Department of Neurosciences, University of California , San Diego, La Jolla, 
      California.
FAU - Staufenberg, Eileen
AU  - Staufenberg E
AD  - 1 Department of Neurosciences, University of California , San Diego, La Jolla, 
      California.
FAU - Collyer, Eileen
AU  - Collyer E
AD  - 1 Department of Neurosciences, University of California , San Diego, La Jolla, 
      California.
FAU - Koffler, Jacob
AU  - Koffler J
AD  - 1 Department of Neurosciences, University of California , San Diego, La Jolla, 
      California.
FAU - Tuszynski, Mark H
AU  - Tuszynski MH
AD  - 1 Department of Neurosciences, University of California , San Diego, La Jolla, 
      California.
AD  - 2 Veterans Administration San Diego Healthcare System , La Jolla, California.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20151113
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Bone Marrow Transplantation/*methods
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - *Motor Activity/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/*physiopathology/*surgery
MH  - Stromal Cells/*transplantation
PMC - PMC4904236
OTO - NOTNLM
OT  - bone marrow stromal cells
OT  - brain-derived neurotrophic factor
OT  - neuroprotection
OT  - severe spinal cord compression
EDAT- 2015/09/29 06:00
MHDA- 2018/01/05 06:00
PMCR- 2017/06/15
CRDT- 2015/09/29 06:00
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
PHST- 2017/06/15 00:00 [pmc-release]
AID - 10.1089/neu.2015.4009 [pii]
AID - 10.1089/neu.2015.4009 [doi]
PST - ppublish
SO  - J Neurotrauma. 2016 Jun 15;33(12):1103-14. doi: 10.1089/neu.2015.4009. Epub 2015 
      Nov 13.