PMID- 26414865
OWN - NLM
STAT- MEDLINE
DCOM- 20160930
LR  - 20151217
IS  - 2158-0022 (Electronic)
IS  - 2158-0014 (Linking)
VI  - 5
IP  - 10
DP  - 2015 Dec
TI  - Motor Readiness Increases Brain Connectivity Between Default-Mode Network and 
      Motor Cortex: Impact on Sampling Resting Periods from fMRI Event-Related Studies.
PG  - 631-40
LID - 10.1089/brain.2014.0332 [doi]
AB  - The default-mode network (DMN) has been implicated in many conditions. One 
      particular function relates to its role in motor preparation. However, the 
      possibly complex relationship between DMN activity and motor preparation has not 
      been fully explored. Dynamic interactions between default mode and motor networks 
      may compromise the ability to evaluate intrinsic connectivity using resting 
      period data extracted from task-based experiments. In this study, we investigated 
      alterations in connectivity between the DMN and the motor network that are 
      associated with motor readiness during the intervals between motor task trials. 
      fMRI data from 20 normal subjects were acquired under three conditions: pure 
      resting state; resting state interleaved with brief, cued right-hand movements at 
      constant intervals (lower readiness); and resting state interleaved with the same 
      movements at unpredictable intervals (higher readiness). The functional 
      connectivity between regions of motor and DMNs was assessed separately for 
      movement periods and intertask intervals. We found a negative relationship 
      between the DMN and the left sensorimotor cortex during the task periods for both 
      motor conditions. Furthermore, during the intertask intervals of the 
      unpredictable condition, the DMN showed a positive relationship with right 
      sensorimotor cortex and a negative relation with the left sensorimotor cortex. 
      These findings indicate a specific modulation on motor processing according to 
      the state of motor readiness. Therefore, connectivity studies using task-based 
      fMRI to probe DMN should consider the influence of motor system modulation when 
      interpreting the results.
FAU - Bazan, Paulo Rodrigo
AU  - Bazan PR
AD  - 1 NIF-LIM-44, Departamento de Radiologia, Hospital das Clinicas da Faculdade de 
      Medicina da Universidade de Sao Paulo , Sao Paulo, Brazil .
AD  - 2 Ciencias Moleculares, Pro-Reitoria de Graduacao, Universidade de Sao Paulo, Sao 
      Paulo , Brazil .
FAU - Biazoli, Claudinei Eduardo Jr
AU  - Biazoli CE Jr
AD  - 1 NIF-LIM-44, Departamento de Radiologia, Hospital das Clinicas da Faculdade de 
      Medicina da Universidade de Sao Paulo , Sao Paulo, Brazil .
AD  - 3 Center of Mathematics, Computation and Cognition, Universidade Federal do ABC , 
      Sao Paulo, Brazil .
FAU - Sato, Joao Ricardo
AU  - Sato JR
AD  - 3 Center of Mathematics, Computation and Cognition, Universidade Federal do ABC , 
      Sao Paulo, Brazil .
FAU - Amaro, Edson Jr
AU  - Amaro E Jr
AD  - 1 NIF-LIM-44, Departamento de Radiologia, Hospital das Clinicas da Faculdade de 
      Medicina da Universidade de Sao Paulo , Sao Paulo, Brazil .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150929
PL  - United States
TA  - Brain Connect
JT  - Brain connectivity
JID - 101550313
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping
MH  - Connectome
MH  - Cues
MH  - Evoked Potentials/physiology
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Membrane Potentials/physiology
MH  - Motor Cortex/*physiology
MH  - Rest/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - connectivity
OT  - default-mode network
OT  - fMRI
OT  - motor network
OT  - movement preparation
OT  - resting state
EDAT- 2015/09/29 06:00
MHDA- 2016/10/01 06:00
CRDT- 2015/09/29 06:00
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2016/10/01 06:00 [medline]
AID - 10.1089/brain.2014.0332 [doi]
PST - ppublish
SO  - Brain Connect. 2015 Dec;5(10):631-40. doi: 10.1089/brain.2014.0332. Epub 2015 Sep 
      29.