PMID- 26414891
OWN - NLM
STAT- MEDLINE
DCOM- 20160630
LR  - 20181202
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 39
IP  - 2
DP  - 2016 Feb 1
TI  - The Association between Obstructive Sleep Apnea on Diabetic Kidney Disease: A 
      Systematic Review and Meta-Analysis.
PG  - 301-8
LID - 10.5665/sleep.5432 [doi]
AB  - STUDY OBJECTIVE: This systematic review aims to investigate the association 
      between obstructive sleep apnea (OSA) and diabetic kidney disease (DKD). METHODS: 
      MeSH terms and free text searches were performed on MEDLINE, EMBASE, and Cochrane 
      Database of Systematic Reviews from inception to April 2015. Zetoc and OpenGrey 
      databases were queried for grey literature, and lastly, hand searches were 
      carried out. Study selection and quality assessment were conducted by two 
      authors. One author carried out data extraction, which was checked by other 
      authors. The relationships between apneahypopnea index (AHI), oxygen desaturation 
      index (ODI), time spent under 90% oxygen saturation (%TST < 90), and minimum and 
      mean oxygen saturation (O2) on DKD were examined. RESULTS: Two longitudinal and 
      ten cross-sectional studies were included for our narrative synthesis, and seven 
      studies for meta-analysis. Studies that performed multi-variable analysis 
      demonstrated significant associations between OSA (assessed using either 
      apnea-hypopnea index or ODI) and DKD in type 2 diabetes mellitus (T2DM). This was 
      confirmed by meta-analysis (pooled OR 1.73, 95% CI: 1.13-2.64). There was some 
      evidence to suggest that %TST < 90 may have an association with DKD. There was 
      insufficient evidence to conclude on the relationship between minimum and mean 
      oxygen saturation on DKD. There was no evidence available on the associations 
      between OSA and other respiratory parameters in type 1 diabetes mellitus 
      populations. CONCLUSIONS: There is moderate evidence that OSA is associated with 
      DKD in patients with T2DM. Large prospective studies with long-term follow up are 
      needed to assess the possible bi-directional mechanisms between OSA and DKD.
CI  - (c) 2016 Associated Professional Sleep Societies, LLC.
FAU - Leong, Wen Bun
AU  - Leong WB
AD  - School of Health and Population Sciences, University of Birmingham.
FAU - Jadhakhan, Ferozkhan
AU  - Jadhakhan F
AD  - Primary Care Clinical Sciences, University of Birmingham, UK.
FAU - Taheri, Shahrad
AU  - Taheri S
AD  - Department of Medicine and Clinical Research Core, Weill Cornell Medical College, 
      New York and Doha Qatar.
AD  - Department of Medicine, King's College London, London, UK.
FAU - Thomas, G Neil
AU  - Thomas GN
AD  - Public Health, Epidemiology and Biostatistics, University of Birmingham, UK.
AD  - Institute of Public Health, Social and Preventive Medicine, Mannheim Medical 
      Faculty, Heidelberg University, Mannheim, Germany.
FAU - Adab, Peymane
AU  - Adab P
AD  - Public Health, Epidemiology and Biostatistics, University of Birmingham, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20160201
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications
MH  - Diabetic Nephropathies/*complications/metabolism
MH  - Humans
MH  - Longitudinal Studies
MH  - Oxygen/metabolism/pharmacology
MH  - Sleep Apnea, Obstructive/*complications/metabolism
PMC - PMC4712397
OTO - NOTNLM
OT  - airway
OT  - albuminuria
OT  - apnea
OT  - creatinine
OT  - diabetes mellitus
OT  - glomerular filtration rate
OT  - nephropathy
OT  - nocturnal hypoxemia
EDAT- 2015/09/29 06:00
MHDA- 2016/07/01 06:00
PMCR- 2016/08/01
CRDT- 2015/09/29 06:00
PHST- 2015/01/27 00:00 [received]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2016/07/01 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - sp-00037-15 [pii]
AID - 10.5665/sleep.5432 [doi]
PST - epublish
SO  - Sleep. 2016 Feb 1;39(2):301-8. doi: 10.5665/sleep.5432.