PMID- 26415786
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20191113
IS  - 1971-3274 (Electronic)
IS  - 0393-5264 (Print)
IS  - 0393-5264 (Linking)
VI  - 30
IP  - 2
DP  - 2015 Apr-Jun
TI  - Sex differences in MDMA-induced toxicity in Sprague-Dawley rats.
PG  - 131-7
AB  - Recent evidence demonstrates that female subjects show exaggerated responses to 
      3,4-methylenedioxymethamphetamine (MDMA) compared with males. The aim of our 
      study was to evaluate sex differences and the role of endogenous gonadal hormones 
      on the effects of MDMA. Fifty-six intact and gonadectomized male and female 
      Sprague-Dawley rats were randomly assigned to either MDMA (5 mg/kg) or saline 
      treatment. Learning and memory were assessed using the Morris water maze (MWM). 
      The expression of Bax and Bcl-2 in the hippocampus was detected by Western 
      blotting. Behavioral analysis showed that MDMA led to memory impairment in both 
      male and female rats. The female rats showed more sensitivity to impairment than 
      the males, as assessed using all the memory parameters in the MWM. Ovariectomy 
      attenuated the MDMA-induced memory impairment. By contrast, orchiectomized rats 
      showed more impairment than MDMA-treated intact male rats. Bcl-2 and Bax were 
      down-regulated and up-regulated in MDMA-treated male and female rats, 
      respectively. MDMA treatment in the orchiectomized rats led to upregulation of 
      Bax and down-regulation of Bcl-2. Ovariectomy attenuated the MDMA-induced 
      up-regulation of Bax and caused more expression of Bcl-2 compared with what was 
      observed in the MDMA-treated intact female rats. In summary, female rats showed 
      exaggerated responses to the effects of MDMA and this may be explained by 
      endogenous gonadal hormones.
FAU - Soleimani Asl, Sara
AU  - Soleimani Asl S
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
FAU - Hamedi Shahraki, Soudabeh
AU  - Hamedi Shahraki S
FAU - Artimani, Tayebeh
AU  - Artimani T
FAU - Joghataei, Mohammad Taghi
AU  - Joghataei MT
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Funct Neurol
JT  - Functional neurology
JID - 8707746
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (bcl-2-Associated X Protein)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Castration
MH  - Female
MH  - Hippocampus/metabolism
MH  - Learning/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Sex Characteristics
MH  - bcl-2-Associated X Protein/metabolism
PMC - PMC4610761
EDAT- 2015/09/30 06:00
MHDA- 2016/06/23 06:00
PMCR- 2015/09/29
CRDT- 2015/09/30 06:00
PHST- 2015/09/30 06:00 [entrez]
PHST- 2015/09/30 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
PHST- 2015/09/29 00:00 [pmc-release]
AID - 7140 [pii]
AID - 131-137 [pii]
AID - 10.11138/fneur/2015.30.2.131 [doi]
PST - ppublish
SO  - Funct Neurol. 2015 Apr-Jun;30(2):131-7. doi: 10.11138/fneur/2015.30.2.131.