PMID- 26416192
OWN - NLM
STAT- MEDLINE
DCOM- 20160321
LR  - 20220311
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Linking)
VI  - 110
IP  - 11
DP  - 2015 Nov
TI  - Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With 
      Celiac Disease: A Systematic Review and Meta-Analysis.
PG  - 1539-48
LID - 10.1038/ajg.2015.296 [doi]
AB  - OBJECTIVES: First-degree relatives (FDRs) of patients with celiac disease (CD) 
      are at high risk for CD and prevalence among them varies from 1.6 to 38%. The 
      risk of having CD among FDRs if the FDR is sister, brother, mother, father, son, 
      or daughter of index patient with CD is not known. We conducted a meta-analysis 
      and calculated pooled prevalence of CD among FDRs, second-degree relatives 
      (SDRs), and specific relations with index patient. METHODS: On search of 
      literature, 2,259 articles appeared of which 54 articles were included in this 
      meta-analysis. Diagnosis of CD was based on standard criteria. RESULTS: Pooled 
      prevalence of CD was 7.5% (95% confidence interval (CI) 6.3%, 8.8%) in 10,252 
      FDRs and 2.3% (95% CI 1.3%, 3.8%) in 642 SDRs. Pooled prevalence of CD was 
      highest in siblings (8.9%), followed by offsprings (7.9%) and parents (3.0%). 
      Female FDRs had higher prevalence than male FDRs (8.4% vs. 5.2%, P=0.047). While 
      sisters and daughters of index patient had the highest risk of having CD (1 in 7 
      and 1 in 8, respectively), the risk was 1 in 13 in sons, 1 in 16 in brothers, 1 
      in 32 in mothers, and 1 in 33 in fathers. There were also differences in the 
      pooled prevalence of CD in FDRs according to their geographic location. 
      CONCLUSIONS: Pooled prevalence of CD among FDRs is 7.5% and varies considerably 
      with their relationship with the index patient. The risk of CD in FDRs also 
      varies according to gender and geographical location.
FAU - Singh, Prashant
AU  - Singh P
AD  - Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
FAU - Arora, Shubhangi
AU  - Arora S
AD  - Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
FAU - Lal, Suman
AU  - Lal S
AD  - Max Healthcare, Gurgaon, India.
FAU - Strand, Tor A
AU  - Strand TA
AD  - Medical Services Division, Innlandet Hospital Trust, Lillehammer, Norway.
FAU - Makharia, Govind K
AU  - Makharia GK
AD  - Department of Gastroenterology and Human Nutrition, All India Institute of 
      Medical Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20150929
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
MH  - Asia/epidemiology
MH  - Celiac Disease/*epidemiology/*genetics
MH  - Europe/epidemiology
MH  - Fathers
MH  - Female
MH  - Humans
MH  - Male
MH  - Mothers
MH  - North America/epidemiology
MH  - *Pedigree
MH  - Prevalence
MH  - Risk Factors
MH  - Sex Factors
MH  - Siblings
MH  - South America/epidemiology
EDAT- 2015/09/30 06:00
MHDA- 2016/03/22 06:00
CRDT- 2015/09/30 06:00
PHST- 2015/03/15 00:00 [received]
PHST- 2015/08/03 00:00 [accepted]
PHST- 2015/09/30 06:00 [entrez]
PHST- 2015/09/30 06:00 [pubmed]
PHST- 2016/03/22 06:00 [medline]
AID - ajg2015296 [pii]
AID - 10.1038/ajg.2015.296 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2015 Nov;110(11):1539-48. doi: 10.1038/ajg.2015.296. Epub 
      2015 Sep 29.