PMID- 26416225 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20231213 IS - 1398-9995 (Electronic) IS - 0105-4538 (Linking) VI - 71 IP - 1 DP - 2016 Jan TI - Tobacco smoke exposure and multiplexed immunoglobulin E sensitization in children: a population-based study. PG - 90-8 LID - 10.1111/all.12775 [doi] AB - BACKGROUND: Although there is evidence that exposure to tobacco smoke is harmful to children's respiratory health, the effects of tobacco smoke exposure on the regulation of immunoglobulin E (IgE)-mediated immune responses to specific allergens remain unclear. This study aimed to investigate the relationship between objectively assessed tobacco smoke exposure and specific IgE profiles for a broad spectrum of allergens in a population setting. METHODS: Children aged 5-18 years (N = 1315) were assessed using serum cotinine measurement and microarray-based multiplexed detection of specific IgE against 40 allergens. RESULTS: Serum cotinine levels were positively associated with sensitization to foods (adjusted odds ratio [AOR] = 4.95; 95% CI: 1.59-15.34), cockroaches (AOR = 3.77; 95% CI: 1.49-9.51), and pollen (AOR = 2.84; 95% CI: 1.20-6.73) while the association was borderline significant for animals (AOR = 2.53; 95% CI: 0.92-6.93). No associations were found for sensitization against mites, mold, and latex. When considering the degree of allergic sensitization, serum cotinine levels were positively correlated to the number of sensitization to cockroaches (P = 0.004), pollen (P = 0.006), and foods (P < 0.001), with statistically significant positive dose-response relationships (all P < 0.01). Similar results were observed when summing up specific IgE concentrations for the aforementioned allergen categories. CONCLUSIONS: The association between tobacco smoke exposure and IgE sensitization to environmental allergens varies for different allergens among children. This study demonstrates that elevated serum cotinine levels are significantly associated with IgE sensitization to cockroaches, grass pollen, and certain foods, with potential dose-dependent relationships. CI - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Yao, T-C AU - Yao TC AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. FAU - Chang, S-W AU - Chang SW AD - Clinical Informatics and Medical Statistics Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Hua, M-C AU - Hua MC AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. FAU - Liao, S-L AU - Liao SL AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. FAU - Tsai, M-H AU - Tsai MH AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. FAU - Lai, S-H AU - Lai SH AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. AD - Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. FAU - Tseng, Y-L AU - Tseng YL AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. FAU - Yeh, K-W AU - Yeh KW AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. FAU - Tsai, H-J AU - Tsai HJ AD - Division of Biostatistics and Bioinformatics, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan. AD - Department of Public Health, China Medical University, Taichung, Taiwan. AD - Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. FAU - Huang, J-L AU - Huang JL AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. CN - PATCH study group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151020 PL - Denmark TA - Allergy JT - Allergy JID - 7804028 RN - 0 (Allergens) RN - 0 (Smoke) RN - 37341-29-0 (Immunoglobulin E) RN - K5161X06LL (Cotinine) SB - IM MH - Adolescent MH - Allergens/immunology MH - Animals MH - Child MH - Child, Preschool MH - Cotinine/blood MH - Environmental Exposure/*adverse effects MH - Female MH - Humans MH - Hypersensitivity/*epidemiology/*etiology MH - Immunization MH - Immunoglobulin E/blood/*immunology MH - Male MH - Odds Ratio MH - Population Surveillance MH - Risk Factors MH - Smoke/*adverse effects MH - Nicotiana/*adverse effects OTO - NOTNLM OT - allergic sensitization OT - children OT - cotinine OT - specific IgE OT - tobacco smoke FIR - Huang, Jing-Long IR - Huang JL FIR - Yao, Tsung-Chieh IR - Yao TC FIR - Hua, Man-Chin IR - Hua MC FIR - Tsai, Ming-Han IR - Tsai MH FIR - Liao, Sui-Ling IR - Liao SL FIR - Lai, Shen-Hao IR - Lai SH FIR - Yeh, Kuo-Wei IR - Yeh KW FIR - Chen, Li-Chen IR - Chen LC FIR - Lee, Wen-I IR - Lee WI FIR - Ou, Liang-Shiou IR - Ou LS EDAT- 2015/09/30 06:00 MHDA- 2016/12/15 06:00 CRDT- 2015/09/30 06:00 PHST- 2015/09/22 00:00 [accepted] PHST- 2015/09/30 06:00 [entrez] PHST- 2015/09/30 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - 10.1111/all.12775 [doi] PST - ppublish SO - Allergy. 2016 Jan;71(1):90-8. doi: 10.1111/all.12775. Epub 2015 Oct 20.