PMID- 26416680
OWN - NLM
STAT- MEDLINE
DCOM- 20160712
LR  - 20190130
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Print)
IS  - 0962-8436 (Linking)
VI  - 370
IP  - 1680
DP  - 2015 Oct 19
TI  - From gristle to chondrocyte transplantation: treatment of cartilage injuries.
PG  - 20140369
LID - 10.1098/rstb.2014.0369 [doi]
LID - 20140369
AB  - This review addresses the progress in cartilage repair technology over the 
      decades with an emphasis on cartilage regeneration with cell therapy. The most 
      abundant cartilage is the hyaline cartilage that covers the surface of our joints 
      and, due to avascularity, this tissue is unable to repair itself. The cartilage 
      degeneration seen in osteoarthritis causes patient suffering and is a huge burden 
      to society. The surgical approach to cartilage repair was non-existing until the 
      1950s when new surgical techniques emerged. The use of cultured cells for cell 
      therapy started as experimental studies in the 1970s that developed over the 
      years to a clinical application in 1994 with the introduction of the autologous 
      chondrocyte transplantation technique (ACT). The technology is now spread 
      worldwide and has been further refined by combining arthroscopic techniques with 
      cells cultured on matrix (MACI technology). The non-regenerating hypothesis of 
      cartilage has been revisited and we are now able to demonstrate cell divisions 
      and presence of stem-cell niches in the joint. Furthermore, cartilage derived 
      from human embryonic stem cells and induced pluripotent stem cells could be the 
      base for new broader cell treatments for cartilage injuries and the future 
      technology base for prevention and cure of osteoarthritis.
CI  - (c) 2015 The Author(s).
FAU - Lindahl, Anders
AU  - Lindahl A
AD  - Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, and 
      Institute of Biomedicine, Department of Clinical Chemistry and Transfusion 
      Medicine, Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden 
      anders.lindahl@clinchem.gu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological 
      sciences
JID - 7503623
SB  - IM
MH  - Animals
MH  - Cartilage/*injuries/surgery
MH  - Cell- and Tissue-Based Therapy
MH  - Cells, Cultured
MH  - Chondrocytes/physiology/*transplantation
MH  - Embryonic Stem Cells/cytology/transplantation
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/transplantation
MH  - Osteoarthritis/therapy
MH  - Regeneration
MH  - Stem Cell Niche
MH  - Transplantation, Autologous
PMC - PMC4633998
OTO - NOTNLM
OT  - cartilage
OT  - cell therapy
OT  - stem cells
EDAT- 2015/09/30 06:00
MHDA- 2016/07/13 06:00
PMCR- 2016/10/19
CRDT- 2015/09/30 06:00
PHST- 2015/09/30 06:00 [entrez]
PHST- 2015/09/30 06:00 [pubmed]
PHST- 2016/07/13 06:00 [medline]
PHST- 2016/10/19 00:00 [pmc-release]
AID - rstb.2014.0369 [pii]
AID - rstb20140369 [pii]
AID - 10.1098/rstb.2014.0369 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2015 Oct 19;370(1680):20140369. doi: 
      10.1098/rstb.2014.0369.