PMID- 26417500
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150929
LR  - 20240323
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 6
IP  - 9
DP  - 2015 Sep 1
TI  - Specific imaging of atherosclerotic plaque lipids with two-wavelength 
      intravascular photoacoustics.
PG  - 3276-86
LID - 10.1364/BOE.6.003276 [doi]
AB  - The lipid content in plaques is an important marker for identifying 
      atherosclerotic lesions and disease states. Intravascular photoacoustic (IVPA) 
      imaging can be used to visualize lipids in the artery. In this study, we further 
      investigated lipid detection in the 1.7-microm spectral range. By exploiting the 
      relative difference between the IVPA signal strengths at 1718 and 1734 nm, we 
      could successfully detect and differentiate between the plaque lipids and 
      peri-adventitial fat in human coronary arteries ex vivo. Our study demonstrates 
      that IVPA imaging can positively identify atherosclerotic plaques using only two 
      wavelengths, which could enable rapid data acquisition in vivo.
FAU - Wu, Min
AU  - Wu M
AD  - Department of Biomedical Engineering, Thorax Center, Erasmus University Medical 
      Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
FAU - Jansen, Krista
AU  - Jansen K
AD  - Department of Biomedical Engineering, Thorax Center, Erasmus University Medical 
      Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands ; Interuniversity 
      Cardiology Institute of The Netherlands-Netherlands Heart Institute, PO Box 
      19258, 3501 DG Utrecht, The Netherlands ; Section Audiology, Department of 
      Otolaryngology-Head and Neck Surgery, and EMGO Institute of Health and Care 
      Research, VU University Medical Center, Amsterdam, The Netherlands.
FAU - van der Steen, Antonius F W
AU  - van der Steen AF
AD  - Department of Biomedical Engineering, Thorax Center, Erasmus University Medical 
      Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands ; Interuniversity 
      Cardiology Institute of The Netherlands-Netherlands Heart Institute, PO Box 
      19258, 3501 DG Utrecht, The Netherlands ; Department of Imaging Science and 
      Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The 
      Netherlands ; Shenzhen Institutes of Advanced Technology, Chinese Academy of 
      Sciences, 518055 Shenzhen, China.
FAU - van Soest, Gijs
AU  - van Soest G
AD  - Department of Biomedical Engineering, Thorax Center, Erasmus University Medical 
      Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20150806
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC4574656
OTO - NOTNLM
OT  - (110.0110) Imaging systems
OT  - (110.5120) Photoacoustic imaging
OT  - (110.5125) Photoacoustics
EDAT- 2015/09/30 06:00
MHDA- 2015/09/30 06:01
PMCR- 2015/08/06
CRDT- 2015/09/30 06:00
PHST- 2015/05/27 00:00 [received]
PHST- 2015/07/02 00:00 [revised]
PHST- 2015/07/03 00:00 [accepted]
PHST- 2015/09/30 06:00 [entrez]
PHST- 2015/09/30 06:00 [pubmed]
PHST- 2015/09/30 06:01 [medline]
PHST- 2015/08/06 00:00 [pmc-release]
AID - 241831 [pii]
AID - 10.1364/BOE.6.003276 [doi]
PST - epublish
SO  - Biomed Opt Express. 2015 Aug 6;6(9):3276-86. doi: 10.1364/BOE.6.003276. 
      eCollection 2015 Sep 1.