PMID- 26418984
OWN - NLM
STAT- MEDLINE
DCOM- 20151222
LR  - 20211203
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 32
IP  - 5
DP  - 2015 Oct
TI  - [Polymorphisms of killer cell immunoglobulin-like receptor and its ligand HLA-I 
      gene among northern Chinese Han population].
PG  - 651-6
LID - 10.3760/cma.j.issn.1003-9406.2015.05.009 [doi]
AB  - OBJECTIVE To investigate the distribution of killer cell immunoglobulin-like 
      receptors (KIR) and their specific ligands human leukocyte antigen-I (HLA-I) gene 
      in northern China. METHODS One hundred and eighty-four unrelated northern Chinese 
      Han individuals were recruited. Genotypes of the KIR and HLA-ABC genes were 
      studied by sequence-specific primer polymerase chain reaction (SSP-PCR). RESULTS 
      Sixteen KIR genes were detected among the 184 unrelated individuals. In all 
      individuals, the four framework genes were present. The frequencies for those 
      carrying the remaining 12 KIR genes have ranged from 16.3% to 99.5%. Twenty-four 
      KIR genotypes were identified, for which half were detected in a single 
      individual. A new genotype comprised of KIR2DL3, 3DL1, 2DP1 and the framework 
      genes was detected in one subject. Respectively, 12, 27 and 11 specificities of 
      HLA alleles were identified on the HLA-A, B, C loci. CONCLUSION The distribution 
      of polymorphisms of KIR and its ligand HLA-ABC genes among northern Chinese Han 
      population have been ascertained. The frequencies of 9 KIR/HLA combinations in 
      the above population have been determined for the first time.
FAU - Wu, Lingyan
AU  - Wu L
AD  - Key Laboratory of Major Diseases in Children of Ministry of Education, Shunyi 
      Maternal and Child Health Hospital, Beijing Pediatric Research Institute, 
      National Key Discipline of Pediatrics, Beijing Children' Hospital, Capital 
      Medical University, Beijing 100045, P.R. China. Email: kunlingshen@hotmail.com.
FAU - Xie, Zhengde
AU  - Xie Z
FAU - Liu, Yali
AU  - Liu Y
FAU - Ai, Junhong
AU  - Ai J
FAU - Liu, Chunyan
AU  - Liu C
FAU - Shen, Kunling
AU  - Shen K
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Child
MH  - China/ethnology
MH  - Ethnicity
MH  - Female
MH  - Gene Frequency
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Receptors, KIR/*genetics
EDAT- 2015/09/30 06:00
MHDA- 2015/12/23 06:00
CRDT- 2015/09/30 06:00
PHST- 2015/09/30 06:00 [entrez]
PHST- 2015/09/30 06:00 [pubmed]
PHST- 2015/12/23 06:00 [medline]
AID - 940632137 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2015.05.009 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Oct;32(5):651-6. doi: 
      10.3760/cma.j.issn.1003-9406.2015.05.009.