PMID- 26418998
OWN - NLM
STAT- MEDLINE
DCOM- 20151222
LR  - 20211203
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 32
IP  - 5
DP  - 2015 Oct
TI  - [Association of single nucleotide polymorphisms of susceptibility genes of type 2 
      diabetes mellitus with liability to gout among ethnic Han Chinese males from 
      coastal region of Shandong].
PG  - 711-4
LID - 10.3760/cma.j.issn.1003-9406.2015.05.023 [doi]
AB  - OBJECTIVE To assess the association of single nucleotide polymorphisms (SNPs) of 
      susceptibility genes of type 2 diabetes mellitus (T2DM) with liability to gout 
      among ethnic Han Chinese males from coastal region of Shandong province. METHODS 
      Seven SNPs within the susceptibility genes of T2DM, including rs10773971(G/C) and 
      rs4766398(G/C) of WNT5B gene, rs10225163(G/C) of JAZF1 gene, rs2069590(T/A) of 
      BDKRB2 gene, rs5745709(G/A) of HGF gene, rs1991914(C/A) of OTOP1 gene and 
      rs2236479(G/A) of COL18A1 gene, were typed with a custom-made Illumina GoldenGate 
      Genotyping assay in 480 male patients with gout and 480 male controls. Potential 
      association was assessed with the chi-square test. RESULTS No significant 
      difference was detected for the 7 selected SNPs in terms of genotypic and allelic 
      frequencies (P > 0.05). When age and body mass index (BMI) were adjusted, the 7 
      genetic variants still showed no significant association with gout. CONCLUSION 
      The genotypes of the 7 selected SNPs are not associated with gout in ethnic Han 
      Chinese male patients from the coastal region of Shandong province. However, the 
      results need to be replicated in larger sets of patients collected from other 
      regions and populations.
FAU - Han, Lin
AU  - Han L
AD  - Shandong Provincial Gout Clinical Medical Center, Department of Metabolic 
      Disease, Department of Pathology, Affiliated Hospital of Qingdao University. 
      Email: jiazt@126.com.
FAU - Xin, Ruosai
AU  - Xin R
FAU - Sun, Jian
AU  - Sun J
FAU - Hou, Feng
AU  - Hou F
FAU - Li, Changgui
AU  - Li C
FAU - Hu, Xinlin
AU  - Hu X
FAU - Liu, Zhen
AU  - Liu Z
FAU - Wang, Yao
AU  - Wang Y
FAU - Li, Xinde
AU  - Li X
FAU - Ren, Wei
AU  - Ren W
FAU - Wang, Xuefeng
AU  - Wang X
FAU - Jia, Zhaotong
AU  - Jia Z
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adult
MH  - Aged
MH  - China/ethnology
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Ethnicity
MH  - *Genetic Predisposition to Disease
MH  - Gout/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2015/09/30 06:00
MHDA- 2015/12/23 06:00
CRDT- 2015/09/30 06:00
PHST- 2015/09/30 06:00 [entrez]
PHST- 2015/09/30 06:00 [pubmed]
PHST- 2015/12/23 06:00 [medline]
AID - 940632151 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2015.05.023 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Oct;32(5):711-4. doi: 
      10.3760/cma.j.issn.1003-9406.2015.05.023.