PMID- 26420011
OWN - NLM
STAT- MEDLINE
DCOM- 20160511
LR  - 20181113
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 14
DP  - 2015 Sep 29
TI  - Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly 
      obese patients: a cohort study.
PG  - 79
LID - 10.1186/s12940-015-0066-z [doi]
LID - 79
AB  - BACKGROUND: In animal experiments persistent organic pollutants (POPs) cause 
      hepatosteatosis. In epidemiological studies POPs have positive associations with 
      serum markers of nonalcoholic fatty liver disease (NAFLD) and together with 
      obesity synergistic association with insulin resistance. Because insulin 
      resistance and obesity are critical in NAFLD pathogenesis, we investigated the 
      association of serum pollutant levels with liver histology and alanine 
      aminotransferase (ALT) in morbidly obese. METHODS: Liver biopsies were from 161 
      participants of the Kuopio Obesity Surgery Study (KOBS) who underwent bariatric 
      surgery 2005-2011. Liver histology was categorized as normal, steatosis and 
      non-alcoholic steatohepatitis (NASH). Liver phenotype at baseline and ALT at 
      baseline and 12 months post-surgery were correlated to serum POP concentrations 
      at respective time points. As lipophilic POPs concentrate to smaller fat volume 
      during weight loss, serum levels before and 12 months after bariatric surgery 
      were compared. RESULTS: Baseline serum concentration of PCB-118, beta-HCH and 
      several PFAAs had an inverse association with lobular inflammation possibly due 
      to changes in bile acid metabolism. ALT had negative associations with many POPs 
      at baseline that turned positive at 12 months after major clinical improvements. 
      There was an interaction between some POPs and sex at 12 months, and in 
      stratified data positive associations were observed mainly in females but not in 
      males. CONCLUSIONS: We found a negative association between serum concentrations 
      of PCB-118, beta-HCH and several PFAAs with lobular inflammation at baseline. 
      Positive POPs-ATL associations at 12 months among women suggest that increased 
      POP concentrations may decrease the degree of liver recovery.
FAU - Rantakokko, Panu
AU  - Rantakokko P
AD  - National Institute for Health and Welfare, Department of Health Protection, 
      Chemicals and Health Unit, Kuopio, Finland. panu.rantakokko@thl.fi.
FAU - Mannisto, Ville
AU  - Mannisto V
AD  - Department of Medicine, University of Eastern Finland and Kuopio University 
      Hospital, Kuopio, Finland. ville.mannisto@kuh.fi.
FAU - Airaksinen, Riikka
AU  - Airaksinen R
AD  - National Institute for Health and Welfare, Department of Health Protection, 
      Chemicals and Health Unit, Kuopio, Finland. riikka.airaksinen@thl.fi.
FAU - Koponen, Jani
AU  - Koponen J
AD  - National Institute for Health and Welfare, Department of Health Protection, 
      Chemicals and Health Unit, Kuopio, Finland. jani.koponen@thl.fi.
FAU - Viluksela, Matti
AU  - Viluksela M
AD  - National Institute for Health and Welfare, Department of Health Protection, 
      Chemicals and Health Unit, Kuopio, Finland. matti.viluksela@thl.fi.
AD  - Department of Environmental Science, University of Eastern Finland, Kuopio, 
      Finland. matti.viluksela@thl.fi.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - National Institute for Health and Welfare, Department of Health Protection, 
      Chemicals and Health Unit, Kuopio, Finland. hannu.kiviranta@thl.fi.
FAU - Pihlajamaki, Jussi
AU  - Pihlajamaki J
AD  - Institute of Public Health and Clinical Nutrition, Department of Clinical 
      Nutrition, University of Eastern Finland, Kuopio, Finland. 
      jussi.pihlajamaki@uef.fi.
AD  - Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, 
      Finland. jussi.pihlajamaki@uef.fi.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150929
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/*blood
MH  - *Bariatric Surgery/statistics & numerical data
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Finland/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/chemically induced/*epidemiology/pathology
MH  - Obesity, Morbid/complications/*epidemiology
PMC - PMC4588245
EDAT- 2015/10/01 06:00
MHDA- 2016/05/12 06:00
PMCR- 2015/09/29
CRDT- 2015/10/01 06:00
PHST- 2015/04/01 00:00 [received]
PHST- 2015/09/17 00:00 [accepted]
PHST- 2015/10/01 06:00 [entrez]
PHST- 2015/10/01 06:00 [pubmed]
PHST- 2016/05/12 06:00 [medline]
PHST- 2015/09/29 00:00 [pmc-release]
AID - 10.1186/s12940-015-0066-z [pii]
AID - 66 [pii]
AID - 10.1186/s12940-015-0066-z [doi]
PST - epublish
SO  - Environ Health. 2015 Sep 29;14:79. doi: 10.1186/s12940-015-0066-z.