PMID- 26420190
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20220317
IS  - 0964-7058 (Print)
IS  - 0964-7058 (Linking)
VI  - 24
IP  - 3
DP  - 2015
TI  - The correlation between high body mass index and survival in patients with 
      esophageal cancer after curative esophagectomy: evidence from retrospective 
      studies.
PG  - 480-8
LID - 10.6133/apjcn.2015.24.3.05 [doi]
AB  - OBJECTIVE: To investigate the predictive value of high body mass index (H-BMI) on 
      the survival of patients with esophageal cancer (EC) after curative 
      esophagectomy. METHODS: Studies were systematically identified to investigate the 
      relationship between overweight and obese (H-BMI) and clinical outcomes in EC 
      patients treated with curative esophagectomy. Measured clinical outcomes were 
      disease-free survival (DFS) and overall survival (OS). The pooled hazard ratio 
      (HR) with 95% confidence interval (CI) was estimated. Subgroup analyses were 
      performed according to tumour type and body mass index (BMI). RESULTS: Fourteen 
      studies with 4823 cases were included in the final pooled quantitative analysis. 
      In EC patients overall, H-BMI was associated with improved DFS (HR, 0.83; 95% CI: 
      0.75-0.90) and OS (HR, 0.79; 95 % CI: 0.73-0.85), as compared with normal BMI. 
      The results were consistent with those who were overweight. Among patients with 
      esophageal adenocarcinoma (EAC), a better prognosis, as reflected by OS, was 
      observed with H-BMI (HR, 0.81; 95% CI: 0.73-0.89). The same results were also 
      observed in EAC patients who were obese and overweight. In contrast, among 
      patients with esophageal squamous cell carcinoma (ESCC), H-BMI was associated 
      with a worse prognosis, as reflected by DFS (HR, 2.26; 95% CI: 1.29-3.24). 
      CONCLUSIONS: H-BMI has distinctly different impacts on the postoperative survival 
      of EAC and ESCC patients. H-BMI is a potential predictor for better prognosis in 
      EC patients overall, and particularly in EAC patients, treated with curative 
      esophagectomy. However, in ESCC patients, H-BMI is a potential predictor for a 
      worse prognosis of postoperative survival.
FAU - Pan, Wenbiao
AU  - Pan W
AD  - Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao-Tong 
      University School of Medicine, Shanghai, China.
AD  - Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao-Tong University 
      School of Medicine, Shanghai, China.
FAU - Sun, Zhiyong
AU  - Sun Z
AD  - Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao-Tong University 
      School of Medicine, Shanghai, China.
FAU - Xiang, Yangwei
AU  - Xiang Y
AD  - Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao-Tong 
      University School of Medicine, Shanghai, China.
FAU - Fang, Wentao
AU  - Fang W
AD  - Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao-Tong University 
      School of Medicine, Shanghai, China. Email: vwtfang@hotmail.com.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asia Pac J Clin Nutr
JT  - Asia Pacific journal of clinical nutrition
JID - 9440304
SB  - IM
MH  - *Body Mass Index
MH  - Disease-Free Survival
MH  - Esophageal Neoplasms/*mortality/*surgery
MH  - *Esophagectomy
MH  - Female
MH  - Humans
MH  - Male
MH  - Postoperative Complications/*mortality
MH  - Retrospective Studies
EDAT- 2015/10/01 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/10/01 06:00
PHST- 2015/10/01 06:00 [entrez]
PHST- 2015/10/01 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.6133/apjcn.2015.24.3.05 [doi]
PST - ppublish
SO  - Asia Pac J Clin Nutr. 2015;24(3):480-8. doi: 10.6133/apjcn.2015.24.3.05.