PMID- 26420953
OWN - NLM
STAT- MEDLINE
DCOM- 20161006
LR  - 20181202
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 21
IP  - 36
DP  - 2015 Sep 28
TI  - Mesenchymal stem cell therapy for cirrhosis: Present and future perspectives.
PG  - 10253-61
LID - 10.3748/wjg.v21.i36.10253 [doi]
AB  - Cirrhosis occurs as a result of various chronic liver injuries, which may be 
      caused by viral infections, alcohol abuse and the administration of drugs and 
      chemicals. Recently, bone marrow cells (BMCs), hematopoietic stem cells (HSCs) 
      and mesenchymal stem cells (MSCs) have been used for developing treatments for 
      cirrhosis. Clinical trials have investigated the therapeutic potential of BMCs, 
      HSCs and MSCs for the treatment of cirrhosis based on their potential to 
      differentiate into hepatocytes. Although the therapeutic mechanisms of BMC, HSC 
      and MSC treatments are still not fully characterized, the evidence thus far has 
      indicated that the potential therapeutic mechanisms of MSCs are clearer than 
      those of BMCs or HSCs with respect to liver regenerative medicine. MSCs suppress 
      inflammatory responses, reduce hepatocyte apoptosis, increase hepatocyte 
      regeneration, reverse liver fibrosis and enhance liver functionality. This paper 
      summarizes the clinical studies that have used BMCs, HSCs and MSCs in patients 
      with liver failure or cirrhosis. We also present the potential therapeutic 
      mechanisms of BMCs, HSCs and MSCs for the improvement of liver function.
FAU - Eom, Young Woo
AU  - Eom YW
AD  - Young Woo Eom, Soon Koo Baik, Cell Therapy and Tissue Engineering Center, Yonsei 
      University Wonju College of Medicine, Wonju 220-701, South Korea.
FAU - Kim, Gaeun
AU  - Kim G
AD  - Young Woo Eom, Soon Koo Baik, Cell Therapy and Tissue Engineering Center, Yonsei 
      University Wonju College of Medicine, Wonju 220-701, South Korea.
FAU - Baik, Soon Koo
AU  - Baik SK
AD  - Young Woo Eom, Soon Koo Baik, Cell Therapy and Tissue Engineering Center, Yonsei 
      University Wonju College of Medicine, Wonju 220-701, South Korea.
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Animals
MH  - Humans
MH  - Liver/pathology/physiopathology/*surgery
MH  - Liver Cirrhosis/diagnosis/physiopathology/*surgery
MH  - Liver Failure/diagnosis/physiopathology/*surgery
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*physiology
MH  - Phenotype
MH  - Recovery of Function
MH  - Treatment Outcome
PMC - PMC4579873
OTO - NOTNLM
OT  - Anti-fibrosis
OT  - Bone marrow cells
OT  - Cell therapy
OT  - Cirrhosis
OT  - Hematopoietic stem cells
OT  - Immune-modulation
OT  - Mesenchymal stem cells
OT  - Trophic factors
EDAT- 2015/10/01 06:00
MHDA- 2016/10/08 06:00
PMCR- 2015/09/28
CRDT- 2015/10/01 06:00
PHST- 2015/01/07 00:00 [received]
PHST- 2015/06/01 00:00 [revised]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/10/01 06:00 [entrez]
PHST- 2015/10/01 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
PHST- 2015/09/28 00:00 [pmc-release]
AID - 10.3748/wjg.v21.i36.10253 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2015 Sep 28;21(36):10253-61. doi: 
      10.3748/wjg.v21.i36.10253.