PMID- 26421847
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20220408
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 9
DP  - 2015
TI  - High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype 
      Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry 
      Program.
PG  - e0139485
LID - 10.1371/journal.pone.0139485 [doi]
LID - e0139485
AB  - Allogeneic hematopoietic stem cell transplantation is a widely used and effective 
      therapy for hematopoietic malignant diseases and numerous other disorders. 
      High-resolution human leukocyte antigen (HLA) haplotype frequency distributions 
      not only facilitate individual donor searches but also determine the probability 
      with which a particular patient can find HLA-matched donors in a registry. The 
      frequencies of the HLA-A, -B, -C, -DRB1, and -DQB1 alleles and haplotypes were 
      estimated among 169,995 Chinese volunteers using the sequencing-based typing 
      (SBT) method. Totals of 191 HLA-A, 244 HLA-B, 146 HLA-C, 143 HLA-DRB1 and 47 
      HLA-DQB1 alleles were observed, which accounted for 6.98%, 7.06%, 6.46%, 9.11% 
      and 7.91%, respectively, of the alleles in each locus in the world (IMGT 3.16 
      Release, Apr. 2014). Among the 100 most common haplotypes from the 169,995 
      individuals, nine distinct haplotypes displayed significant regionally specific 
      distributions. Among these, three were predominant in the South China region 
      (i.e., the 20th, 31st, and 81sthaplotypes), another three were predominant in the 
      Southwest China region (i.e., the 68th, 79th, and 95th haplotypes), one was 
      predominant in the South and Southwest China regions (the 18th haplotype), one 
      was relatively common in the Northeast and North China regions (the 94th 
      haplotype), and one was common in the Northeast, North and Northwest China (the 
      40th haplotype). In conclusion, this is the first to analyze high-resolution HLA 
      diversities across the entire country of China, based on a detailed and complete 
      data set that covered 31 provinces, autonomous regions, and municipalities. 
      Specifically, we also evaluated the HLA matching probabilities within and between 
      geographic regions and analyzed the regional differences in the HLA diversities 
      in China. We believe that the data presented in this study might be useful for 
      unrelated HLA-matched donor searches, donor registry planning, population genetic 
      studies, and anthropogenesis studies.
FAU - Zhou, Xiao-Yang
AU  - Zhou XY
AD  - The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of 
      Geriatrics, Ministry of Health, Beijing, China; Quality control laboratory, China 
      Bone Marrow Program, Beijing, China.
FAU - Zhu, Fa-Ming
AU  - Zhu FM
AD  - HLA Laboratory, Zhejiang Blood Center, Hangzhou, Zhejiang, China.
FAU - Li, Jian-Ping
AU  - Li JP
AD  - HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China.
FAU - Mao, Wei
AU  - Mao W
AD  - HLA Laboratory, Chongqing Blood Center, Chongqing, China.
FAU - Zhang, De-Mei
AU  - Zhang DM
AD  - HLA Laboratory, Taiyuan Red Cross Blood Center, Taiyuan, Shanxi, China.
FAU - Liu, Meng-Li
AU  - Liu ML
AD  - HLA Laboratory, Shaanxi Blood Center, Xi'an, Shaanxi, China.
FAU - Hei, Ai-Lian
AU  - Hei AL
AD  - The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of 
      Geriatrics, Ministry of Health, Beijing, China; Quality control laboratory, China 
      Bone Marrow Program, Beijing, China.
FAU - Dai, Da-Peng
AU  - Dai DP
AD  - The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of 
      Geriatrics, Ministry of Health, Beijing, China; Quality control laboratory, China 
      Bone Marrow Program, Beijing, China.
FAU - Jiang, Ping
AU  - Jiang P
AD  - The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of 
      Geriatrics, Ministry of Health, Beijing, China; Quality control laboratory, China 
      Bone Marrow Program, Beijing, China.
FAU - Shan, Xiao-Yan
AU  - Shan XY
AD  - HLA Laboratory, Beijing Red Cross Blood Center, Beijing, China.
FAU - Zhang, Bo-Wei
AU  - Zhang BW
AD  - HLA Laboratory, Henan Blood Center, Zhengzhou, Henan, China.
FAU - Zhu, Chuan-Fu
AU  - Zhu CF
AD  - HLA Laboratory, Shandong Blood Center, Jinan, Shandong.
FAU - Shen, Jie
AU  - Shen J
AD  - HLA Laboratory, the First Affiliated Hospital of Nanjing Medical University, 
      Nanjing, Jiangsu, China.
FAU - Deng, Zhi-Hui
AU  - Deng ZH
AD  - The Key Laboratory of Histocompatibility and Immunogenetics, Shenzhen Blood 
      Center, Shenzhen, Guangdong, China.
FAU - Wang, Zheng-Lei
AU  - Wang ZL
AD  - HLA Laboratory, Hebei Blood Center, Shijiazhuang, Hebei, China.
FAU - Yu, Wei-Jian
AU  - Yu WJ
AD  - HLA Laboratory, Dalian Red Cross Blood Center, Dalian, Liaoning, China.
FAU - Chen, Qiang
AU  - Chen Q
AD  - HLA Laboratory, Institute of Blood Transfusion, Chinese Academy of Medical 
      Sciences & Peking Union Medical College, Chengdu, Sichuan, China.
FAU - Qiao, Yan-Hui
AU  - Qiao YH
AD  - HLA Laboratory, Xinjiang Blood Center, Urumchi, Xinjiang, China.
FAU - Zhu, Xiang-Ming
AU  - Zhu XM
AD  - HLA Laboratory, Kunming Blood Center, Kunming, Yunnan, China.
FAU - Lv, Rong
AU  - Lv R
AD  - HLA Laboratory, Hefei Red Cross Blood Center, Hefei, Anhui, China.
FAU - Li, Guo-Ying
AU  - Li GY
AD  - HLA Laboratory, Gansu Red Cross Blood Center, Lanzhou, Gansu, China.
FAU - Li, Guo-Liang
AU  - Li GL
AD  - HLA Laboratory, Jiangxi Blood Center, Nanchang, Jiangxi, China.
FAU - Li, Heng-Cong
AU  - Li HC
AD  - HLA Laboratory, Nanning Blood Center, Nanning, Guangxi, China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - HLA Laboratory, Liaoning Blood Center, Shenyang, Liaoning, China.
FAU - Pei, Bin
AU  - Pei B
AD  - HLA Laboratory, Xiamen Blood Center, Xiamen, Fujian, China.
FAU - Jiao, Li-Xin
AU  - Jiao LX
AD  - HLA Laboratory, Changchun Blood Center, Changchun, Jilin, China.
FAU - Shen, Gang
AU  - Shen G
AD  - HLA Laboratory, Wuhan Blood Center, Wuhan, Hubei, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - HLA Laboratory, Harbin Red Cross Blood Center, Harbin, Heilongjiang, China.
FAU - Feng, Zhi-Hui
AU  - Feng ZH
AD  - HLA Laboratory, Qingdao Blood Center, Qingdao, Shandong, China.
FAU - Su, Yu-Ping
AU  - Su YP
AD  - HLA Laboratory, Yueyang Red Cross Blood Center, Yueyang, Hunan, China.
FAU - Xu, Zhao-Xia
AU  - Xu ZX
AD  - HLA Laboratory, Changsha Blood Center, Changsha, Hunan, China.
FAU - Di, Wen-Ying
AU  - Di WY
AD  - HLA Laboratory, Soochow Red Cross Blood Center, Suzhou, Jiangsu, China.
FAU - Jiang, Yao-Qin
AU  - Jiang YQ
AD  - HLA Laboratory, Shanghai Blood Center, Shanghai, China.
FAU - Fu, Hong-Lei
AU  - Fu HL
AD  - HLA Laboratory, BFR Transplant Diagnostic Service Center, Beijing China.
FAU - Liu, Xiang-Jun
AU  - Liu XJ
AD  - HLA Laboratory, BFR Transplant Diagnostic Service Center, Beijing China.
FAU - Liu, Xiang
AU  - Liu X
AD  - HLA Laboratory, CapitalBio Corporation, Beijing, China.
FAU - Zhou, Mei-Zhen
AU  - Zhou MZ
AD  - HLA Laboratory, Beijing Genomics Institute, Shenzhen, Guangdong, China.
FAU - Du, Dan
AU  - Du D
AD  - Department of HLA Technology, China Bone Marrow Program, Beijing, China.
FAU - Liu, Qi
AU  - Liu Q
AD  - Department of HLA Technology, China Bone Marrow Program, Beijing, China.
FAU - Han, Ying
AU  - Han Y
AD  - Department of HLA Technology, China Bone Marrow Program, Beijing, China.
FAU - Zhang, Zhi-Xin
AU  - Zhang ZX
AD  - The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of 
      Geriatrics, Ministry of Health, Beijing, China; Quality control laboratory, China 
      Bone Marrow Program, Beijing, China.
FAU - Cai, Jian-Ping
AU  - Cai JP
AD  - The Key Laboratory of Geriatrics, Beijing hospital & Beijing Institute of 
      Geriatrics, Ministry of Health, Beijing, China; Quality control laboratory, China 
      Bone Marrow Program, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150930
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Bone Marrow/*immunology
MH  - China
MH  - Female
MH  - *Gene Frequency
MH  - Genetic Association Studies
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - Volunteers
MH  - Young Adult
PMC - PMC4589403
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/10/01 06:00
MHDA- 2016/04/20 06:00
PMCR- 2015/09/30
CRDT- 2015/10/01 06:00
PHST- 2015/02/12 00:00 [received]
PHST- 2015/09/13 00:00 [accepted]
PHST- 2015/10/01 06:00 [entrez]
PHST- 2015/10/01 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
PHST- 2015/09/30 00:00 [pmc-release]
AID - PONE-D-15-06541 [pii]
AID - 10.1371/journal.pone.0139485 [doi]
PST - epublish
SO  - PLoS One. 2015 Sep 30;10(9):e0139485. doi: 10.1371/journal.pone.0139485. 
      eCollection 2015.