PMID- 26422188
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 57
IP  - 3
DP  - 2016
TI  - EBV-associated Burkitt lymphoma in Taiwan is not age-related.
PG  - 644-53
LID - 10.3109/10428194.2015.1076928 [doi]
AB  - This study retrospectively investigated 54 cases of sporadic Burkitt lymphoma in 
      Taiwan with histopathology review, immunohistochemistry, Epstein-Barr virus (EBV) 
      in situ hybridization (EBER) and fluorescence in situ hybridization (FISH). The 
      great majority revealed typical immunophenotype and 89% (47/53) cases expressed 
      myc protein. EBER was positive in 20% (11/54) of cases, more frequently with 
      nodal presentation, but not significantly associated with age (pediatric vs. 
      adult), abdominal vs. extra-abdominal presentation or overall survival (OS). MYC 
      and IGH were rearranged in 94% (46/49) and 85% (41/48) of cases, respectively. 
      The concordance rate between myc expression and MYC translocation was 83% 
      (40/48). By univariate analysis, OS was statistically associated with age, with 
      or without chemotherapy, central nervous system (CNS) involvement, CNS 
      prophylaxis and leukemic transformation, but not gender, nodal vs. extranodal 
      involvement, stage, immunohistochemistry, EBER, myc expression, MYC translocation 
      or radiotherapy. By multivariate analysis, CNS involvement at presentation and 
      administration of chemotherapy were statistically associated with OS.
FAU - Chen, Bo-Jung
AU  - Chen BJ
AD  - a Department of Pathology , Shuang Ho Hospital, Taipei Medical University , New 
      Taipei City , Taiwan .
FAU - Chang, Sheng-Tsung
AU  - Chang ST
AD  - b Department of Pathology , Chi-Mei Medical Center , Tainan , Taiwan .
AD  - c Department of Nursing , National Tainan Institute of Nursing , Tainan , Taiwan 
      .
FAU - Weng, Shih-Feng
AU  - Weng SF
AD  - d Department of Healthcare Administration and Medical Informatics , Kaohsiung 
      Medical University , Kaohsiung , Taiwan .
FAU - Huang, Wan-Ting
AU  - Huang WT
AD  - e Department of Pathology , Kaohsiung Chang Gung Memorial Hospital-Kaohsiung 
      Medical Center , Kaohsiung , Taiwan .
AD  - f College of Medicine , Kaohsiung and Chang Gung University , Kaohsiung , Taiwan 
      .
FAU - Chu, Pei-Yi
AU  - Chu PY
AD  - g Department of Pathology , St. Martin De Porres Hospital , Chiayi , Taiwan .
AD  - h School of Medicine , Fu-Jen Catholic University , New Taipei City , Taiwan .
FAU - Hsieh, Pin-Pen
AU  - Hsieh PP
AD  - i Department of Pathology and Laboratory Medicine , Kaohsiung Veterans General 
      Hospital , Kaohsiung , Taiwan .
AD  - j National Defense Medical Center , Taipei , Taiwan .
FAU - Jung, Yun-Chih
AU  - Jung YC
AD  - k Department of Pathology , Sin-Lau Christian Hospital , Tainan , Taiwan .
FAU - Kuo, Chun-Chi
AU  - Kuo CC
AD  - b Department of Pathology , Chi-Mei Medical Center , Tainan , Taiwan .
FAU - Chuang, Yu-Ting
AU  - Chuang YT
AD  - l Department of Pathology , National Cheng Kung University Hospital , Tainan , 
      Taiwan , and.
FAU - Chuang, Shih-Sung
AU  - Chuang SS
AD  - b Department of Pathology , Chi-Mei Medical Center , Tainan , Taiwan .
AD  - m Department of Pathology, College of Medicine , Taipei Medical University and 
      National Taiwan University , Taipei , Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150930
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Burkitt Lymphoma/diagnosis/*epidemiology/*etiology/therapy
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Epstein-Barr Virus Infections/*complications/virology
MH  - Female
MH  - *Herpesvirus 4, Human/genetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Analysis
MH  - Taiwan/epidemiology
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Burkitt lymphoma
OT  - EBV
OT  - MYC
OT  - Taiwan
OT  - fluorescence in situ hybridization
EDAT- 2015/10/01 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/10/01 06:00
PHST- 2015/10/01 06:00 [entrez]
PHST- 2015/10/01 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.3109/10428194.2015.1076928 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2016;57(3):644-53. doi: 10.3109/10428194.2015.1076928. Epub 2015 
      Sep 30.