PMID- 26422620
OWN - NLM
STAT- MEDLINE
DCOM- 20160714
LR  - 20211203
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 88
IP  - 4
DP  - 2015 Oct
TI  - Klotho upregulation by rapamycin protects against vascular disease in CKD.
PG  - 660-2
LID - 10.1038/ki.2015.223 [doi]
AB  - Medial arterial calcification involves chondrogenic/osteogenic 
      transdifferentiation of vascular smooth muscle cells (VSMCs). Zhao et al. report 
      that phosphate activates the mammalian target of rapamycin (mTOR) cascade in 
      VSMCs, leading to downregulation of Klotho. Furthermore, rapamycin was shown to 
      halt medial calcification. This effect was blunted in the absence of Klotho. 
      Given the concomitant anti-atherosclerotic effects of the mTOR inhibitor, this 
      agent has clinical potential as an inhibitor of intimal atherosclerosis and 
      medial calcification.
FAU - Hamano, Takayuki
AU  - Hamano T
AD  - Department of Comprehensive Kidney Disease Research, Osaka University Graduate 
      School of Medicine, Osaka, Japan.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.2.1.31 (Glucuronidase)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
CON - Kidney Int. 2015 Oct;88(4):711-21. PMID: 26061549
MH  - Animals
MH  - Aorta, Abdominal/*drug effects
MH  - Aorta, Thoracic/*drug effects
MH  - Aortic Diseases/*prevention & control
MH  - Glucuronidase/*metabolism
MH  - Humans
MH  - Protein Kinase Inhibitors/*pharmacology
MH  - Sirolimus/*pharmacology
MH  - TOR Serine-Threonine Kinases/*antagonists & inhibitors
MH  - Vascular Calcification/*prevention & control
EDAT- 2015/10/01 06:00
MHDA- 2016/07/15 06:00
CRDT- 2015/10/01 06:00
PHST- 2015/10/01 06:00 [entrez]
PHST- 2015/10/01 06:00 [pubmed]
PHST- 2016/07/15 06:00 [medline]
AID - S2157-1716(15)32269-3 [pii]
AID - 10.1038/ki.2015.223 [doi]
PST - ppublish
SO  - Kidney Int. 2015 Oct;88(4):660-2. doi: 10.1038/ki.2015.223.