PMID- 26423141 OWN - NLM STAT- MEDLINE DCOM- 20160512 LR - 20220330 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 15 DP - 2015 Sep 30 TI - Prevalence and association of asthma and allergic sensitization with dietary factors in schoolchildren: data from the french six cities study. PG - 993 LID - 10.1186/s12889-015-2320-2 [doi] LID - 993 AB - BACKGROUND: The prevalence of asthma and allergy has recently risen among children. This increase in prevalence might be related to various factors, particularly diet. The aim of this study is to assess the prevalence and association of asthma and allergic sensitization with dietary factors in the French Six Cities Study. METHODS: Cross-sectional studies were performed among 7432 schoolchildren aged 9-11 years in Bordeaux, Clermont-Ferrand, Creteil, Marseille, Reims, and Strasbourg. Parental questionnaires, based on the International Study on Asthma and Allergies in Childhood (ISAAC), were used to collect information on allergic diseases and potential exposure factors including a food frequency questionnaire to evaluate dietary habits. Skin prick testing to common allergens for allergic sensitization and bronchial hyper-responsiveness (BHR) testing to exercise were performed. Confounders control was performed with multiple logistic regressions. RESULTS: Asthma symptoms, asthma and allergic sensitization were more prevalent in boys than in girls and were more prevalent in the South than in the North of France. After adjustment for confounders, fruit juice intake was associated with a low prevalence of lifetime asthma (ORa [95 % CI]; 0.73 [0.56-0.97]), butter intake was positively associated with atopic wheeze (1.48 [1.07-2.05]) and having lunch at the canteen 1-2 times/week compared to never or occasionally was associated with a lower prevalence of past year wheeze (0.71 [0.52-0.96]), lifetime asthma (0.76 [0.60-0.96]) and allergic sensitization (0.80 [0.67-0.95]). Meat intake was inversely related to past year wheeze among atopic children (0.68 [0.50-0.98]) while fast food consumption and butter intake were associated with an increase prevalence of asthma (2.39 [1.47-3.93] and 1.51 [1.17-2.00] respectively). Fish intake was associated with a lower prevalence of asthma among non-atopic children (0.61 [0.43-0.87]. None of the dietary factors was associated with BHR. CONCLUSIONS: Diet is associated with wheeze, asthma and allergic sensitization but not with BHR in children. These results provide further evidence that adherence to a healthy diet including fruits, meat and fish seems to have a protective effect on asthma and allergy in childhood. However, prospective and experimental studies are needed to provide causal evidence concerning the effect of diet on asthma and atopy. FAU - Saadeh, Danielle AU - Saadeh D AD - Clinical and Epidemiological Research Laboratory, Lebanese University, Hadath, Lebanon. daniellesaadeh@hotmail.com. AD - INSERM U897, Institut de Sante Publique d'Epidemiologie et de Developpement, Laboratoire Sante Travail Environnement, Universite de Bordeaux, Bordeaux, France. daniellesaadeh@hotmail.com. FAU - Salameh, Pascale AU - Salameh P AD - Clinical and Epidemiological Research Laboratory, Lebanese University, Hadath, Lebanon. pascalesalameh1@hotmail.com. FAU - Caillaud, Denis AU - Caillaud D AD - Hopital Gabriel Montpied, Clermont-Ferrand, France. dcaillaud@chu-clermontferrand.fr. FAU - Charpin, Denis AU - Charpin D AD - Hopital Nord, Marseille, France. denisandre.charpin@ap-hm.fr. FAU - De Blay, Frederic AU - De Blay F AD - Hopital Civil, Strasbourg, France. frederic.deblay@chru-strasbourg.fr. FAU - Kopferschmitt, Christine AU - Kopferschmitt C AD - Hopital Civil, Strasbourg, France. christine.kopferschmitt@wanadoo.fr. FAU - Lavaud, Francois AU - Lavaud F AD - Hopital Maison Blanche, Reims, France. flavaud@chu-reims.fr. FAU - Annesi-Maesano, Isabella AU - Annesi-Maesano I AD - EPAR, UMR-S 1136, Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Universities, Paris, France. Isabella.annesi-maesano@inserm.fr. FAU - Baldi, Isabelle AU - Baldi I AD - INSERM U897, Institut de Sante Publique d'Epidemiologie et de Developpement, Laboratoire Sante Travail Environnement, Universite de Bordeaux, Bordeaux, France. isabelle.baldi@isped.u-bordeaux2.fr. FAU - Raherison, Chantal AU - Raherison C AD - INSERM U897, Institut de Sante Publique d'Epidemiologie et de Developpement, Laboratoire Sante Travail Environnement, Universite de Bordeaux, Bordeaux, France. chantal.raherison@isped.u-bordeaux2.fr. AD - Service des Maladies Respiratoires, Hopital du Haut-Leveque, Avenue de Magellan, Pessac, France. chantal.raherison@isped.u-bordeaux2.fr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150930 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Allergens) SB - IM MH - Adult MH - Allergens/immunology MH - Animals MH - *Asthma/epidemiology/etiology/prevention & control MH - Child MH - Cities MH - Cross-Sectional Studies MH - *Diet MH - *Feeding Behavior MH - Female MH - France/epidemiology MH - Fruit MH - Humans MH - *Hypersensitivity/epidemiology/etiology/prevention & control MH - Logistic Models MH - Male MH - Middle Aged MH - Odds Ratio MH - Prevalence MH - Prospective Studies MH - Surveys and Questionnaires MH - Urban Population PMC - PMC4589972 EDAT- 2015/10/02 06:00 MHDA- 2016/05/14 06:00 PMCR- 2015/09/30 CRDT- 2015/10/02 06:00 PHST- 2015/05/21 00:00 [received] PHST- 2015/09/22 00:00 [accepted] PHST- 2015/10/02 06:00 [entrez] PHST- 2015/10/02 06:00 [pubmed] PHST- 2016/05/14 06:00 [medline] PHST- 2015/09/30 00:00 [pmc-release] AID - 10.1186/s12889-015-2320-2 [pii] AID - 2320 [pii] AID - 10.1186/s12889-015-2320-2 [doi] PST - epublish SO - BMC Public Health. 2015 Sep 30;15:993. doi: 10.1186/s12889-015-2320-2.