PMID- 26424937
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151001
LR  - 20200930
IS  - 0899-8280 (Print)
IS  - 0899-8280 (Linking)
VI  - 28
IP  - 4
DP  - 2015 Oct
TI  - Dual antiplatelet compared to triple antithrombotic therapy in anterior wall 
      acute myocardial infarction complicated by depressed left ventricular ejection 
      fraction.
PG  - 445-9
AB  - Current guidelines recommend triple antithrombotic therapy (TT) consisting of 
      warfarin, aspirin, and a P2Y12 inhibitor following an anterior ST elevation 
      myocardial infarction (STEMI) complicated by extensive wall motion abnormalities. 
      This recommendation, however, is based on data collected before percutaneous 
      coronary intervention (PCI) became the standard of care for the treatment of 
      STEMI. We designed a retrospective study of patients who received PCI for 
      anterior STEMI over an 8-year period to compare rates of thromboembolic and 
      bleeding events between patients receiving dual antiplatelet therapy (DAPT) and 
      those receiving TT, including warfarin. Patients were included if the 
      predischarge echocardiogram showed extensive wall motion abnormality and an 
      ejection fraction </=35%. Patients with known left ventricular thrombus were 
      excluded. A total of 124 patients met the criteria, with 80 patients in the DAPT 
      group and 44 in the TT group. The median age was 58 years in the TT group and 64 
      years in the DAPT group (P < 0.04), with an average ejection fraction of 31%. 
      Thromboembolic events occurred in 4 patients (5%) in the DAPT group compared with 
      3 patients (6.8%) in the TT group (P = 0.70). Bleeding occurred in 2 patients in 
      the DAPT group and 4 patients in the TT group (2.5% in DAPT vs. 9.1% in TT group, 
      P = 0.18). No differences in rates of clinical embolism or left ventricular 
      thrombus were found. Our data support recent findings that warfarin may not be 
      indicated for patients following PCI for anterior STEMI, even when significant 
      wall motion abnormalities and reduced ejection fraction </=35% are present.
FAU - Oyetayo, Ola O
AU  - Oyetayo OO
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - Slicker, Kipp
AU  - Slicker K
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - De La Rosa, Lisa
AU  - De La Rosa L
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - Lane, Wesley
AU  - Lane W
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - Langsjoen, Dane
AU  - Langsjoen D
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - Patel, Chhaya
AU  - Patel C
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - Brough, Kevin
AU  - Brough K
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - Michel, Jeffrey
AU  - Michel J
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
FAU - Chiles, Christopher
AU  - Chiles C
AD  - Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science 
      Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of 
      Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal 
      Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health 
      Science Center, and Baylor Scott & White Health, Temple, Texas.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Proc (Bayl Univ Med Cent)
JT  - Proceedings (Baylor University. Medical Center)
JID - 9302033
PMC - PMC4569220
EDAT- 2015/10/02 06:00
MHDA- 2015/10/02 06:01
PMCR- 2015/10/01
CRDT- 2015/10/02 06:00
PHST- 2015/10/02 06:00 [entrez]
PHST- 2015/10/02 06:00 [pubmed]
PHST- 2015/10/02 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - bumc0028-0445 [pii]
AID - 10.1080/08998280.2015.11929303 [doi]
PST - ppublish
SO  - Proc (Bayl Univ Med Cent). 2015 Oct;28(4):445-9. doi: 
      10.1080/08998280.2015.11929303.