PMID- 26425133
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151001
LR  - 20220330
IS  - 1742-6405 (Print)
IS  - 1742-6405 (Electronic)
IS  - 1742-6405 (Linking)
VI  - 12
DP  - 2015
TI  - Development of cryptococcal immune reconstitution inflammatory syndrome 41 months 
      after the initiation of antiretroviral therapy in an AIDS patient.
PG  - 33
LID - 10.1186/s12981-015-0075-6 [doi]
LID - 33
AB  - Cryptococcal meningitis is one of the most lethal fungal infections in patients 
      with acquired immune deficiency syndrome (AIDS). The incidence of and mortality 
      from cryptococcal meningitis have markedly decreased since the introduction of 
      combination antiretroviral therapy (cART). However, despite its benefits, the 
      initiation of cART results in immune reconstitution inflammatory syndrome (IRIS) 
      in some patients. Although IRIS is occasionally difficult to distinguish from 
      relapse or treatment failure, the distinction is important because IRIS requires 
      a different treatment. Here, we present the case of a patient with AIDS who 
      developed symptoms of cryptococcal IRIS 41 months after starting cART. To the 
      best of our knowledge, the time between cART initiation and the onset of 
      cryptococcal IRIS in this patient is the longest that has been reported in the 
      literature.
FAU - Hashimoto, Hideki
AU  - Hashimoto H
AD  - Department of Infectious Diseases, The University of Tokyo Hospital, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8655 Japan.
FAU - Hatakeyama, Shuji
AU  - Hatakeyama S
AD  - Department of Infectious Diseases, The University of Tokyo Hospital, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8655 Japan ; Division of General Internal Medicine/Division 
      of Infectious Diseases, Jichi Medical University Hospital, 3311-1 Yakushiji, 
      Shimotsuke-shi, Tochigi, 329-0498 Japan.
FAU - Yotsuyanagi, Hiroshi
AU  - Yotsuyanagi H
AD  - Department of Infectious Diseases, The University of Tokyo Hospital, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8655 Japan.
LA  - eng
PT  - Journal Article
DEP - 20150930
PL  - England
TA  - AIDS Res Ther
JT  - AIDS research and therapy
JID - 101237921
PMC - PMC4589178
OTO - NOTNLM
OT  - AIDS
OT  - Antiretroviral therapy
OT  - Cryptococcus
OT  - HIV infection
OT  - Immune reconstitution inflammatory syndrome
EDAT- 2015/10/02 06:00
MHDA- 2015/10/02 06:01
PMCR- 2015/09/30
CRDT- 2015/10/02 06:00
PHST- 2015/07/30 00:00 [received]
PHST- 2015/09/23 00:00 [accepted]
PHST- 2015/10/02 06:00 [entrez]
PHST- 2015/10/02 06:00 [pubmed]
PHST- 2015/10/02 06:01 [medline]
PHST- 2015/09/30 00:00 [pmc-release]
AID - 75 [pii]
AID - 10.1186/s12981-015-0075-6 [doi]
PST - epublish
SO  - AIDS Res Ther. 2015 Sep 30;12:33. doi: 10.1186/s12981-015-0075-6. eCollection 
      2015.