PMID- 26425388
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151001
LR  - 20220408
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 6
IP  - 5
DP  - 2015 Sep
TI  - The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease.
PG  - 331-41
LID - 10.14336/AD.2015.0825 [doi]
AB  - Aging is a normal physiological process accompanied by cognitive decline. This 
      aging process has been the primary risk factor for development of aging-related 
      diseases such as Alzheimer's disease (AD). Cognitive deficit is related to 
      alterations of neurotrophic factors level such as brain-derived neurotrophic 
      factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic 
      factor (GDNF). These strong relationship between aging and AD is important to 
      investigate the time which they overlap, as well as, the pathophysiological 
      mechanism in each event. Considering that aging and AD are related to cognitive 
      impairment, here we discuss the involving these neurotrophic factors in the aging 
      process and AD.
FAU - Budni, Josiane
AU  - Budni J
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Bellettini-Santos, Tatiani
AU  - Bellettini-Santos T
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Mina, Francielle
AU  - Mina F
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Garcez, Michelle Lima
AU  - Garcez ML
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Zugno, Alexandra Ioppi
AU  - Zugno AI
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151001
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC4567216
OTO - NOTNLM
OT  - Aging
OT  - Alzheimer's disease
OT  - BNDF
OT  - GDNF
OT  - NGF
EDAT- 2015/10/02 06:00
MHDA- 2015/10/02 06:01
PMCR- 2015/10/01
CRDT- 2015/10/02 06:00
PHST- 2015/06/11 00:00 [received]
PHST- 2015/08/25 00:00 [accepted]
PHST- 2015/10/02 06:00 [entrez]
PHST- 2015/10/02 06:00 [pubmed]
PHST- 2015/10/02 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - ad-6-5-331 [pii]
AID - 10.14336/AD.2015.0825 [doi]
PST - epublish
SO  - Aging Dis. 2015 Oct 1;6(5):331-41. doi: 10.14336/AD.2015.0825. eCollection 2015 
      Sep.