PMID- 26425466
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151001
LR  - 20200930
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 19
IP  - 5
DP  - 2015 Sep-Oct
TI  - Profile of liver enzymes in non-alcoholic fatty liver disease in patients with 
      impaired glucose tolerance and newly detected untreated type 2 diabetes.
PG  - 597-601
LID - 10.4103/2230-8210.163172 [doi]
AB  - CONTEXT: The perception of non-alcoholic fatty liver disease (NAFLD) as an 
      uncommon and benign condition is rapidly changing. Approximately, 70% type 2 
      diabetes mellitus (T2DM) patients have a fatty liver, which may follow an 
      aggressive course with necroinflammation and fibrosis. AIMS: To assess the 
      profile of liver enzymes in subjects with impaired glucose tolerance (IGT), new 
      onset treatment naive T2DM and normal glucose tolerance (NGT) with and without 
      NAFLD. SETTINGS AND DESIGN: Cross-sectional clinic-based study. SUBJECTS AND 
      METHODS: 152 IGT and 158 recently detected T2DM subjects aged between 30 and 69 
      years, along with 160 age and gender matched controls with NGT. An 
      ultrasonography scan of the upper abdomen was done in all patients in order to 
      examine presence of fatty liver. Anthropometry, lipid profile, liver enzymes were 
      also analyzed in all patients. STATISTICAL ANALYSIS USED: Unpaired t-test, 
      Chi-square/Fisher Exact test (for categorical variables), Pearson/Spearmen 
      correlation test to find significant difference, association and correlation 
      between two or more groups respectively. RESULTS: NAFLD was significantly 
      associated with higher alanine aminotransferase (ALT) and gamma-glutamyl 
      transferase (GGT) but not ALP levels in IGT and T2DM patients. ALT, GGT 
      significant correlated with waist circumference, body mass index, fasting 
      insulin, homeostatic model assessment- insulin resistance, fasting blood glucose, 
      high density lipoprotein cholesterol, triglyceride. 57% of NAFLD patients had 
      normal ALT between 25 and 40 U/L, 53% of NAFLD subjects had normal GGT between 15 
      and 30 U/L. ALT <25 U/L and GGT <15 U/L had highest negative predictivity whereas 
      ALT >40 U/L and GGT > 30 U/L had highest positive predictivity for presence of 
      NAFLD in our study sample. CONCLUSIONS: Mild elevations of liver enzymes in the 
      upper normal range are associated with features of metabolic syndrome and NAFLD 
      even in IGT and recently detected T2DM patients. Novel cut-offs for liver enzymes 
      are warranted in order to prevent unnecessary diagnostic work-ups and early 
      detection of NAFLD to reduce the risk of cirrhosis, hepatocellular carcinoma and 
      classical cardiovascular disease in T2DM and IGT patients.
FAU - Sanyal, Debmalya
AU  - Sanyal D
AD  - Department of Endocrinology, KPC Medical College, Jadavpur, Kolkata, West Bengal, 
      India.
FAU - Mukherjee, Pradip
AU  - Mukherjee P
AD  - Department of Endocrinology, IPGME and R and SSKM Hospital, Bhowanipore, Kolkata, 
      West Bengal, India.
FAU - Raychaudhuri, Moutusi
AU  - Raychaudhuri M
AD  - Department of Paediatric Endocrinology, Institute of Child Health, Ballygunge, 
      Kolkata, West Bengal, India.
FAU - Ghosh, Sujoy
AU  - Ghosh S
AD  - Department of Endocrinology, IPGME and R and SSKM Hospital, Bhowanipore, Kolkata, 
      West Bengal, India.
FAU - Mukherjee, Satinath
AU  - Mukherjee S
AD  - Department of Endocrinology, IPGME and R and SSKM Hospital, Bhowanipore, Kolkata, 
      West Bengal, India.
FAU - Chowdhury, Subhankar
AU  - Chowdhury S
AD  - Department of Endocrinology, IPGME and R and SSKM Hospital, Bhowanipore, Kolkata, 
      West Bengal, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC4566337
OTO - NOTNLM
OT  - Impaired glucose tolerance
OT  - nonalcoholic fatty liver disease
OT  - novel cut-offs for liver enzymes
OT  - type 2 diabetes mellitus
EDAT- 2015/10/02 06:00
MHDA- 2015/10/02 06:01
PMCR- 2015/09/01
CRDT- 2015/10/02 06:00
PHST- 2015/10/02 06:00 [entrez]
PHST- 2015/10/02 06:00 [pubmed]
PHST- 2015/10/02 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - IJEM-19-597 [pii]
AID - 10.4103/2230-8210.163172 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2015 Sep-Oct;19(5):597-601. doi: 
      10.4103/2230-8210.163172.