PMID- 26425608
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151001
LR  - 20181113
IS  - 2324-7096 (Print)
IS  - 2324-7096 (Electronic)
IS  - 2324-7096 (Linking)
VI  - 2
IP  - 2
DP  - 2014 Apr-Jun
TI  - Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency 
      Syndrome related to Cryptococcal Meningoencephalitis.
PG  - 2324709614533951
LID - 10.1177/2324709614533951 [doi]
LID - 2324709614533951
AB  - Background. Highly active antiretroviral therapy (HAART) has contributed to 
      reducing the occurrence of opportunistic infections and mortality in human 
      immunodeficiency virus (HIV) infected patients. However, a paradoxical worsening 
      of clinical signs and symptoms among patients during HAART may occur. Immune 
      reconstitution inflammatory syndrome (IRIS) is described as a paradoxical 
      deterioration of clinical status on initiation of HAART in patients with HIV 
      infection. Case Report. We describe the case of a 41-year-old man with 
      opportunistic cryptococcal encephalitis who exhibited neurological and 
      radiological deterioration during the course of HAART. A diagnosis of central 
      nervous system (CNS)-IRIS was based on a decrease of HIV-RNA viral load greater 
      than 1 log, with an increase in CD4(+) T-cell count from baseline. Conclusions. 
      Differential diagnosis of this paradoxical deterioration in clinical and 
      neurological status from overwhelming opportunistic infection is important; it 
      enables an avoidance of unnecessary diagnostic procedures and proper management 
      of this HIV-associated CNS disorder.
FAU - Park, Ji Young
AU  - Park JY
AD  - Kosin University College of Medicine, Busan, Korea.
FAU - Kim, Min Jeong
AU  - Kim MJ
AD  - Kosin University College of Medicine, Busan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140430
PL  - United States
TA  - J Investig Med High Impact Case Rep
JT  - Journal of investigative medicine high impact case reports
JID - 101624758
PMC - PMC4528883
OTO - NOTNLM
OT  - highly active antiretroviral therapy
OT  - human immunodeficiency virus
OT  - immune reconstitution inflammatory syndrome
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2014/04/01 00:00
MHDA- 2014/04/01 00:01
PMCR- 2014/04/01
CRDT- 2015/10/02 06:00
PHST- 2015/10/02 06:00 [entrez]
PHST- 2014/04/01 00:00 [pubmed]
PHST- 2014/04/01 00:01 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.1177_2324709614533951 [pii]
AID - 10.1177/2324709614533951 [doi]
PST - epublish
SO  - J Investig Med High Impact Case Rep. 2014 Apr 30;2(2):2324709614533951. doi: 
      10.1177/2324709614533951. eCollection 2014 Apr-Jun.