PMID- 26425885
OWN - NLM
STAT- MEDLINE
DCOM- 20160217
LR  - 20221207
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 100
IP  - 11
DP  - 2015 Nov
TI  - Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric 
      Bypass in Chinese Obese Patients.
PG  - 4222-30
LID - 10.1210/jc.2015-2884 [doi]
AB  - CONTEXT: Bile acids (BAs) have been suggested as key mediators of the 
      improvements in glucose metabolism after Roux-en-Y gastric bypass (RYGB). 
      OBJECTIVE: The objective of the study was to test whether the individual or a 
      group of BAs have potential value to predict diabetes remission after RYGB. 
      DESIGN AND PATIENTS: A retrospective cohort of 38 Chinese obese patients with 
      type 2 diabetes mellitus (T2DM) who had undergone RYGB and a cross-sectional 
      cohort of 327 subjects from the Shanghai Obesity Study were involved in the 
      study. MAIN OUTCOME AND MEASURES: We applied a targeted metabolomics approach to 
      quantitatively measure 26 serum BAs. The relative proportion of each BA in total 
      BAs was calculated. RESULTS: In the metabolic surgery study, RYGB was effective 
      in the reduction of body weight in both remission and nonremission groups. The 
      reductions of body mass index (BMI) in both groups were 7.34 +/- 2.10 kg/m(2) and 
      6.31 +/- 2.38 kg/m(2), respectively (P = .14). Patients in the remission group had 
      a shorter duration of diabetes, lower glycated hemoglobin, and higher C-peptide 
      and chenodeoxycholic acid (CDCA) proportion at baseline compared with the 
      nonremission group. Multiple logistic regression indicated that a higher level of 
      CDCA relative to total BA (CDCA%) and shorter duration of diabetes at baseline 
      were associated with a greater chance of diabetes remission. The odd ratios were 
      0.19 (95% confidence interval 0.05-0.74) and 1.77 (95% confidence interval 
      1.13-2.76), respectively, after adjustment for age, gender, and BMI. In the 
      cross-sectional study, CDCA% was significantly higher in obese individuals with 
      T2DM than the normal glucose tolerance group. Correlation analysis showed CDCA% 
      was positively correlated with BMI, glycated hemoglobin, triglycerides, and 
      low-density lipoprotein cholesterol and negatively correlated with high-density 
      lipoprotein cholesterol and diabetes duration. CONCLUSION: Increased CDCA, a 
      major primary BA, was correlated with a shorter duration of T2DM, which was 
      associated with a higher possibility of remission after surgery. CDCA% might act 
      as a potential prognostic marker of RYGB.
FAU - Yu, Haoyong
AU  - Yu H
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Ni, Yan
AU  - Ni Y
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Bao, Yuqian
AU  - Bao Y
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Zhang, Pin
AU  - Zhang P
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Zhao, Aihua
AU  - Zhao A
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Chen, Tianlu
AU  - Chen T
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Xie, Guoxiang
AU  - Xie G
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Tu, Yinfang
AU  - Tu Y
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Su, Mingming
AU  - Su M
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Wei, Li
AU  - Wei L
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Jia, Wei
AU  - Jia W
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
FAU - Jia, Weiping
AU  - Jia W
AD  - Departments of Endocrinology and Metabolism (H.Y., Y.B., Y.T., L.Z., L.W., W.J.) 
      and General Surgery (P.Z.) and Center for Translational Medicine (Y.N., A.Z., 
      T.C., G.X., M.S., Wei..J., Weip..J.), Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Clinical Center of Diabetes (H.Y., Y.B., Y.T., L.Z., L.W., 
      W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., Y.B., Y.T., L.Z., 
      L.W., W.J.), Shanghai Key Clinical Center for Metabolic Disease (H.Y., Y.B., 
      Y.T., L.Z., L.W., W.J.), Shanghai Key Laboratory of Diabetes Mellitus (H.Y., 
      Y.B., Y.T., L.Z., L.W., W.J.), Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China; University of Hawaii Cancer Center 
      (Y.N., G.X., M.S., Wei.J.), Honolulu, Hawaii 96813.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151001
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Biomarkers)
RN  - 0GEI24LG0J (Chenodeoxycholic Acid)
SB  - IM
MH  - Adult
MH  - *Anastomosis, Roux-en-Y
MH  - Asian People
MH  - Bile Acids and Salts/blood
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Chenodeoxycholic Acid/*blood
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/*surgery
MH  - Overweight/surgery
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2015/10/02 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/10/02 06:00
PHST- 2015/10/02 06:00 [entrez]
PHST- 2015/10/02 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - 10.1210/jc.2015-2884 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2015 Nov;100(11):4222-30. doi: 10.1210/jc.2015-2884. 
      Epub 2015 Oct 1.