PMID- 26426834
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20191210
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Linking)
VI  - 27
IP  - 12
DP  - 2015 Dec
TI  - Diagnosis of bile acid diarrhoea by fasting and postprandial measurements of 
      fibroblast growth factor 19.
PG  - 1399-402
LID - 10.1097/MEG.0000000000000476 [doi]
AB  - BACKGROUND: A deficiency in the ileal hormone fibroblast growth factor 19 (FGF19) 
      has been described in patients with bile acid diarrhoea (BAD), but fasting FGF19 
      levels have insufficient diagnostic power. We assess whether single postprandial 
      sampling of FGF19 has greater discriminative value than fasting FGF19 for 
      detection of BAD and we evaluate the reproducibility of fasting FGF19. MATERIALS 
      AND METHODS: Twenty-six patients consecutively referred to Se homocholic acid 
      retention test (SeHCAT) were included. Serum FGF19 was measured after an 
      overnight fast and again 1 h postprandially and again in the fasting state 1 week 
      later. RESULTS: Nine of 26 patients had SeHCAT less than 10% and fasting FGF19 
      was lower [median 62 pg/ml, interquartile range (IQR): 47-67] than in the 17 
      diarrhoea controls with SeHCAT at least 10% (median 103 pg/ml, IQR: 77-135, 
      P=0.006). Postprandial FGF19 in BAD patients (61 pg/ml, IQR: 48-69) was similar 
      to fasting values (P=0.59) and increased insignificantly in diarrhoea controls 
      (137 pg/ml, IQR: 88-182; P=0.25). The difference in postprandial FGF19 between 
      patients with BAD and diarrhoea controls was highly significant (P<0.001). 
      CONCLUSION: The difference in serum FGF19 between groups of patients with BAD and 
      diarrhoea controls is amplified postprandially. Within each group, the difference 
      between fasting and postprandial FGF19 was not statistically significant. Further 
      investigations are warranted on stimulated FGF19 response to elucidate its role 
      in BAD.
FAU - Borup, Christian
AU  - Borup C
AD  - Departments of aInternal Medicine bClinical Biochemistry cClinical Physiology, 
      Koge Hospital, Koge dDepartment of Clinical Physiology, Hvidovre Hospital, 
      Hvidovre eDepartment of Internal Medicine and Clinical Research Unit, Gentofte 
      Hospital, Hellerup fFaculty of Health and Human Sciences, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Syversen, Charlotte
AU  - Syversen C
FAU - Bouchelouche, Pierre
AU  - Bouchelouche P
FAU - Damgaard, Morten
AU  - Damgaard M
FAU - Graff, Jesper
AU  - Graff J
FAU - Rumessen, Juri Johannes
AU  - Rumessen JJ
FAU - Munck, Lars Kristian
AU  - Munck LK
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Biomarkers)
RN  - 0 (FGF19 protein, human)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bile Acids and Salts/*metabolism
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Diarrhea/*diagnosis
MH  - Fasting/physiology
MH  - Female
MH  - Fibroblast Growth Factors/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period/physiology
MH  - Prospective Studies
MH  - Reproducibility of Results
EDAT- 2015/10/02 06:00
MHDA- 2016/08/16 06:00
CRDT- 2015/10/02 06:00
PHST- 2015/10/02 06:00 [entrez]
PHST- 2015/10/02 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - 10.1097/MEG.0000000000000476 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2015 Dec;27(12):1399-402. doi: 
      10.1097/MEG.0000000000000476.