PMID- 26427424
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20220408
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 854
DP  - 2016
TI  - Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with 
      Retinitis Pigmentosa.
PG  - 291-7
LID - 10.1007/978-3-319-17121-0_39 [doi]
AB  - The purpose of this study was to correlate features on flood-illuminated adaptive 
      optics (AO) images with color fundus, fundus autofluorescence (FAF) and spectral 
      domain optical coherence tomography (SD-OCT) images in patients with retinitis 
      pigmentosa (RP). We imaged 39 subjects diagnosed with RP using the rtx1 
      flood-illuminated AO camera from Imagine Eyes (Orsay, France). We observed a 
      correlation between hyper-autofluoresence changes on FAF, disruption of the 
      interdigitation zone (IZ) on SD-OCT and loss of reflective cone profiles on AO. 
      Four main patterns of cone-reflectivity were seen on AO: presumed healthy cone 
      mosaics, hypo-reflective blurred cone-like structures, higher frequency 
      disorganized hyper-reflective spots, and lower frequency hypo-reflective spots. 
      These regions were correlated to progressive phases of cone photoreceptor 
      degeneration observed using SD-OCT and FAF. These results help provide 
      interpretation of en face images obtained by flood-illuminated AO in subjects 
      with RP. However, significant ambiguity remains as to what truly constitutes a 
      cone, especially in areas of degeneration. With further refinements in 
      technology, flood illuminated AO imaging has the potential to provide rapid, 
      standardized, longitudinal and lower cost imaging in patients with retinal 
      degeneration.
FAU - Gale, Michael J
AU  - Gale MJ
AD  - Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science 
      University, 97239, Portland, OR, USA. galem@ohsu.edu.
FAU - Feng, Shu
AU  - Feng S
AD  - Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science 
      University, 97239, Portland, OR, USA. feng@ohsu.edu.
FAU - Titus, Hope E
AU  - Titus HE
AD  - Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science 
      University, 97239, Portland, OR, USA. hopeetitus@gmail.com.
FAU - Smith, Travis B
AU  - Smith TB
AD  - Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science 
      University, 97239, Portland, OR, USA. smittrav@ohsu.edu.
FAU - Pennesi, Mark E
AU  - Pennesi ME
AD  - Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science 
      University, 97239, Portland, OR, USA.
LA  - eng
GR  - K08EY02118601/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Lipofuscin)
SB  - IM
MH  - Fluorescence
MH  - Humans
MH  - Lipofuscin/chemistry/metabolism
MH  - Microscopy, Confocal/methods
MH  - Ophthalmoscopy/*methods
MH  - Reproducibility of Results
MH  - Retina/*pathology
MH  - Retinal Cone Photoreceptor Cells/pathology
MH  - Retinal Pigment Epithelium/chemistry/metabolism/pathology
MH  - Retinitis Pigmentosa/*diagnosis
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
OTO - NOTNLM
OT  - Cone photoreceptors
OT  - Flood
OT  - Illuminated adaptive optics
OT  - Multimodal imaging
OT  - Retinal degeneration
OT  - Retinitis pigmentosa
EDAT- 2015/10/03 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/10/03 06:00
PHST- 2015/10/03 06:00 [entrez]
PHST- 2015/10/03 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - 10.1007/978-3-319-17121-0_39 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2016;854:291-7. doi: 10.1007/978-3-319-17121-0_39.