PMID- 26430761
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20220331
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 31
IP  - 2
DP  - 2016 Feb
TI  - Preterm birth and/or low birth weight are associated with periodontal disease and 
      the increased placental immunohistochemical expression of inflammatory markers.
PG  - 231-7
LID - 10.14670/HH-11-671 [doi]
AB  - The objective of this study was to determine whether gynecological and 
      periodontal clinical parameters and the immunohistochemical expression in 
      placental chorionic villi of the markers cyclooxygenase-2 (COX-2), interleukin 
      (IL)-1beta, vascular endothelial growth factor receptor 1 (VEGFR1), podoplanin, and 
      Heat Shock Protein 70 (HSP70) are associated with preterm birth (PB) and/or low 
      birth weight (LBW) neonates. MATERIAL AND METHODS: An observational case-control 
      study was performed in 130 puerperal women: mothers of PB/LBW neonates (cases, 
      n=65) and mothers of full-term normal-weight neonates (controls, n=65). Data were 
      gathered from all participants on socio-demographic, gynecological, and 
      periodontal variables and on placental immunohistochemical COX-2, IL-1beta, VEGFR1, 
      podoplanin, and HSP70 expression. RESULTS: Among the 42 women with mild/moderate 
      periodontitis or gingivitis, the studied periodontal variables were significantly 
      worse and the placental COX-2 (p=0.043), HSP70 (p=0.001), IL-1beta (p=0.001), VEGFR1 
      (p=0.032), and podoplanin (p=0.058) expressions were significantly higher in the 
      cases than in the controls. In comparison to the mothers without periodontitis, 
      only COX-2 (p=0.026) and VEGFR1 (p=0.005) expressions were significantly 
      increased in those with the disease. Increased COX-2 values were detected in the 
      women with a history of genitourinary infection (p=0.036), premature rupture of 
      membrane (p=0.012), or drug treatment (p=0.050). CONCLUSIONS: The etiology of 
      preterm birth and/or low birth weight is multifactorial and involves consumption 
      habits, social-health factors, and infectious episodes. These adverse pregnancy 
      outcomes were associated with periodontitis and the increased placental 
      expression of IL-1beta, COX-2, VEGFR1, and HSP70.
FAU - Pozo, Elena
AU  - Pozo E
AD  - Private practice in periodontics, Granada, Spain.
FAU - Mesa, Francisco
AU  - Mesa F
AD  - Periodontology Department, School of Dentistry, University of Granada, Spain.
FAU - Ikram, Mohamed H
AU  - Ikram MH
AD  - Private practice in periodontics, Granada, Spain.
FAU - Puertas, Alberto
AU  - Puertas A
AD  - Department of Obstetrics and Gynecology, Virgen de las Nieves University 
      Hospital, Granada, Spain.
FAU - Torrecillas-Martinez, Laura
AU  - Torrecillas-Martinez L
AD  - Oral Surgery Department, School of Dentistry, University of Granada, Spain.
FAU - Ortega-Oller, Inmaculada
AU  - Ortega-Oller I
AD  - Oral Surgery Department, School of Dentistry, University of Granada, Spain.
FAU - Magan-Fernandez, Antonio
AU  - Magan-Fernandez A
AD  - Periodontology Department, School of Dentistry, University of Granada, Spain.
FAU - Rodriguez-Martinez, Maria Dolores
AU  - Rodriguez-Martinez MD
AD  - Pathology Department, School of Medicine, University of Granada, Granada, Spain.
FAU - Padial-Molina, Miguel
AU  - Padial-Molina M
AD  - Oral Surgery Department, School of Dentistry, University of Granada, Spain and 
      Department of Periodontics and Oral Medicine, School of Dentistry, University of 
      Michigan, Ann Arbor, MI, USA.
FAU - Sanchez-Fernandez, Elena
AU  - Sanchez-Fernandez E
AD  - Oral Surgery Department, School of Dentistry, University of Granada, Spain.
FAU - Galindo-Moreno, Pablo
AU  - Galindo-Moreno P
AD  - Oral Surgery Department, School of Dentistry, University of Granada, Spain.
FAU - O'Valle, Francisco
AU  - O'Valle F
AD  - Pathology Department, School of Medicine, University of Granada, Granada, Spain. 
      fovalle@ugr.es.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150929
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
RN  - 0 (Biomarkers)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (IL1B protein, human)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (PDPN protein, human)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
EIN - Histol Histopathol. 2020 Oct;35(10):1211. PMID: 33305349
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Cyclooxygenase 2/metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - HSP70 Heat-Shock Proteins/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - *Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Inflammation
MH  - Interleukin-1beta/metabolism
MH  - Membrane Glycoproteins/metabolism
MH  - Periodontal Diseases/*complications/physiopathology
MH  - Periodontitis/metabolism
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Pregnancy Outcome
MH  - *Premature Birth
MH  - Vascular Endothelial Growth Factor Receptor-1/metabolism
EDAT- 2015/10/03 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/10/03 06:00
PHST- 2015/10/03 06:00 [entrez]
PHST- 2015/10/03 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - HH-11-671 [pii]
AID - 10.14670/HH-11-671 [doi]
PST - ppublish
SO  - Histol Histopathol. 2016 Feb;31(2):231-7. doi: 10.14670/HH-11-671. Epub 2015 Sep 
      29.