PMID- 26430812
OWN - NLM
STAT- MEDLINE
DCOM- 20160816
LR  - 20160314
IS  - 1934-6638 (Electronic)
IS  - 1934-662X (Linking)
VI  - 124
IP  - 3
DP  - 2016 Mar
TI  - Two-tiered subdivision of atypia on urine cytology can improve patient follow-up 
      and optimize the utility of UroVysion.
PG  - 188-95
LID - 10.1002/cncy.21630 [doi]
AB  - BACKGROUND: The annual incidence of urothelial carcinoma continues to increase, 
      and it is projected that greater than 70,000 new cases will occur in the year 
      2015. However, as much as 23% of cytologic specimens will demonstrate some degree 
      of atypia without meeting the criteria for urothelial carcinoma and thus will be 
      reported as atypical. METHODS: The authors conducted 2 laboratory information 
      searches and 1 survey. In total, 311 patients who had atypical cytology-biopsy 
      pairs available were identified from the initial data search. The second data 
      search identified 942 patients who had fluorescence in situ hybridization (FISH) 
      results available. RESULTS: There was fair agreement between FISH results and 
      cytology results (kappa = 0.34; 95% confidence interval, 0.27-0.41). The analysis did 
      not reveal any benefits of using additional atypical subcategories beyond the 2 
      suggested in the literature. It was determined that 2 strategies would provide an 
      optimal balance: standardizing patient management and facilitating the adoption 
      of universally recognized templates. CONCLUSIONS: When combining cytology and the 
      2-tiered atypical classification system with FISH testing, a marked increase in 
      sensitivity and an accompanying decrease in specificity were observed compared 
      with either test individually. Thus, highly sensitive FISH testing may help to 
      identify high-risk patients among those in the group with uncertain atypical 
      findings.
CI  - (c) 2015 American Cancer Society.
FAU - Glass, Ryan E
AU  - Glass RE
AD  - Department of Pathology, North Shore-LIJ Staten Island University Hospital, 
      Staten Island, New York.
FAU - Coutsouvelis, Constantinos
AU  - Coutsouvelis C
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
FAU - Sheikh-Fayyaz, Silvat
AU  - Sheikh-Fayyaz S
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
FAU - Chau, Karen
AU  - Chau K
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
FAU - Rosen, Lisa
AU  - Rosen L
AD  - Department of Biostatistics, Feinstein Institute for Medical Research, North 
      Shore-LIJ Health System, Manhasset, New York.
FAU - Brenkert, Ryan
AU  - Brenkert R
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
FAU - Slim, Farah
AU  - Slim F
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
FAU - Epelbaum, Fanya
AU  - Epelbaum F
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
FAU - Das, Kasturi
AU  - Das K
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
FAU - Cocker, Rubina S
AU  - Cocker RS
AD  - Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New 
      York.
LA  - eng
PT  - Journal Article
DEP - 20151002
PL  - United States
TA  - Cancer Cytopathol
JT  - Cancer cytopathology
JID - 101499453
SB  - IM
MH  - Follow-Up Studies
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Urinary Bladder Neoplasms/diagnosis
MH  - Urine/*cytology
OTO - NOTNLM
OT  - 2-tiered system
OT  - Paris system
OT  - UroVysion
OT  - atypical
OT  - atypical urine
OT  - fluorescence in situ hybridization (FISH)
OT  - urine
EDAT- 2015/10/03 06:00
MHDA- 2016/08/17 06:00
CRDT- 2015/10/03 06:00
PHST- 2015/07/23 00:00 [received]
PHST- 2015/09/01 00:00 [revised]
PHST- 2015/09/08 00:00 [accepted]
PHST- 2015/10/03 06:00 [entrez]
PHST- 2015/10/03 06:00 [pubmed]
PHST- 2016/08/17 06:00 [medline]
AID - 10.1002/cncy.21630 [doi]
PST - ppublish
SO  - Cancer Cytopathol. 2016 Mar;124(3):188-95. doi: 10.1002/cncy.21630. Epub 2015 Oct 
      2.