PMID- 26432480
OWN - NLM
STAT- MEDLINE
DCOM- 20190124
LR  - 20190124
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1862
IP  - 3
DP  - 2016 Mar
TI  - Bone marrow-derived macrophages and the CNS: An update on the use of experimental 
      chimeric mouse models and bone marrow transplantation in neurological disorders.
PG  - 310-22
LID - S0925-4439(15)00289-6 [pii]
LID - 10.1016/j.bbadis.2015.09.017 [doi]
AB  - The central nervous system (CNS) is a very unique system with multiple features 
      that differentiate it from systemic tissues. One of the most captivating aspects 
      of its distinctive nature is the presence of the blood brain barrier (BBB), which 
      seals it from the periphery. Therefore, to preserve tissue homeostasis, the CNS 
      has to rely heavily on resident cells such as microglia. These pivotal cells of 
      the mononuclear lineage have important and dichotomous roles according to various 
      neurological disorders. However, certain insults can overwhelm microglia as well 
      as compromising the integrity of the BBB, thus allowing the infiltration of bone 
      marrow-derived macrophages (BMDMs). The use of myeloablation and bone marrow 
      transplantation allowed the generation of chimeric mice to study resident 
      microglia and infiltrated BMDM separately. This breakthrough completely 
      revolutionized the way we captured these 2 types of mononuclear phagocytic cells. 
      We now realize that microglia and BMDM exhibit distinct features and appear to 
      perform different tasks. Since these cells are central in several pathologies, it 
      is crucial to use chimeric mice to analyze their functions and mechanisms to 
      possibly harness them for therapeutic purpose. This review will shed light on the 
      advent of this methodology and how it allowed deciphering the ontology of 
      microglia and its maintenance during adulthood. We will also compare the 
      different strategies used to perform myeloablation. Finally, we will discuss the 
      landmark studies that used chimeric mice to characterize the roles of microglia 
      and BMDM in several neurological disorders. This article is part of a Special 
      Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus 
      Schwaninger.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Larochelle, Antoine
AU  - Larochelle A
AD  - Neuroscience Laboratory, CHU de Quebec Research Center, Department of Molecular 
      Medicine, Faculty of Medicine, Laval University, 2705 Laurier Blvd., Quebec G1V 
      4G2, Canada.
FAU - Bellavance, Marc-Andre
AU  - Bellavance MA
AD  - Neuroscience Laboratory, CHU de Quebec Research Center, Department of Molecular 
      Medicine, Faculty of Medicine, Laval University, 2705 Laurier Blvd., Quebec G1V 
      4G2, Canada.
FAU - Michaud, Jean-Philippe
AU  - Michaud JP
AD  - Neuroscience Laboratory, CHU de Quebec Research Center, Department of Molecular 
      Medicine, Faculty of Medicine, Laval University, 2705 Laurier Blvd., Quebec G1V 
      4G2, Canada.
FAU - Rivest, Serge
AU  - Rivest S
AD  - Neuroscience Laboratory, CHU de Quebec Research Center, Department of Molecular 
      Medicine, Faculty of Medicine, Laval University, 2705 Laurier Blvd., Quebec G1V 
      4G2, Canada. Electronic address: Serge.Rivest@crchudequebec.ulaval.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151008
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
SB  - IM
MH  - Animals
MH  - *Bone Marrow Transplantation/methods
MH  - Brain/metabolism/pathology
MH  - Central Nervous System/metabolism/*pathology
MH  - Disease Models, Animal
MH  - Humans
MH  - Macrophages/metabolism/*pathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Microglia/metabolism/pathology
MH  - Nervous System Diseases/genetics/*pathology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Bone marrow
OT  - Chimeric mice
OT  - Multiple sclerosis
OT  - Myeloid cells
OT  - Stroke
EDAT- 2015/10/04 06:00
MHDA- 2019/01/25 06:00
CRDT- 2015/10/04 06:00
PHST- 2015/05/12 00:00 [received]
PHST- 2015/09/17 00:00 [revised]
PHST- 2015/09/25 00:00 [accepted]
PHST- 2015/10/04 06:00 [entrez]
PHST- 2015/10/04 06:00 [pubmed]
PHST- 2019/01/25 06:00 [medline]
AID - S0925-4439(15)00289-6 [pii]
AID - 10.1016/j.bbadis.2015.09.017 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2016 Mar;1862(3):310-22. doi: 10.1016/j.bbadis.2015.09.017. 
      Epub 2015 Oct 8.