PMID- 26433146
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 297
DP  - 2016 Jan 15
TI  - Brain-derived neurotrophic factor into adult neocortex strengthens a taste 
      aversion memory.
PG  - 1-4
LID - S0166-4328(15)30206-0 [pii]
LID - 10.1016/j.bbr.2015.09.034 [doi]
AB  - Nowadays, it is known that brain derived neurotrophic-factor (BDNF) is a protein 
      critically involved in regulating long-term memory related mechanisms. Previous 
      studies from our group in the insular cortex (IC), a brain structure of the 
      temporal lobe implicated in acquisition, consolidation and retention of 
      conditioned taste aversion (CTA), demonstrated that BDNF is essential for CTA 
      consolidation. Recent studies show that BDNF-TrkB signaling is able to mediate 
      the enhancement of memory. However, whether BDNF into neocortex is able to 
      enhance aversive memories remains unexplored. In the present work, we 
      administrated BDNF in a concentration capable of inducing in vivo neocortical 
      LTP, into the IC immediately after CTA acquisition in two different conditions: a 
      "strong-CTA" induced by 0.2M lithium chloride i.p. as unconditioned stimulus, and 
      a "weak-CTA" induced by 0.1M lithium chloride i.p. Our results show that infusion 
      of BDNF into the IC converts a weak CTA into a strong one, in a TrkB 
      receptor-dependent manner. The present data suggest that BDNF into the adult 
      insular cortex is sufficient to increase an aversive memory-trace.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Martinez-Moreno, Araceli
AU  - Martinez-Moreno A
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico.
FAU - Rodriguez-Duran, Luis F
AU  - Rodriguez-Duran LF
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico.
FAU - Escobar, Martha L
AU  - Escobar ML
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico. Electronic address: 
      mescobar@unam.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151001
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nootropic Agents)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/*drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Catheters, Indwelling
MH  - Conditioning, Psychological/drug effects/physiology
MH  - Lithium Chloride
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Microinjections
MH  - Neocortex/*drug effects/physiology
MH  - Nootropic Agents/*pharmacology
MH  - Rats, Wistar
MH  - Taste Perception/*drug effects/physiology
MH  - Water Deprivation
OTO - NOTNLM
OT  - BDNF
OT  - CTA
OT  - Memory enhancement
EDAT- 2015/10/04 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/10/04 06:00
PHST- 2015/08/07 00:00 [received]
PHST- 2015/09/23 00:00 [revised]
PHST- 2015/09/25 00:00 [accepted]
PHST- 2015/10/04 06:00 [entrez]
PHST- 2015/10/04 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - S0166-4328(15)30206-0 [pii]
AID - 10.1016/j.bbr.2015.09.034 [doi]
PST - ppublish
SO  - Behav Brain Res. 2016 Jan 15;297:1-4. doi: 10.1016/j.bbr.2015.09.034. Epub 2015 
      Oct 1.