PMID- 26433250
OWN - NLM
STAT- MEDLINE
DCOM- 20151230
LR  - 20180302
IS  - 1471-5007 (Electronic)
IS  - 1471-4922 (Linking)
VI  - 31
IP  - 10
DP  - 2015 Oct
TI  - Regulation of the Immune Response to alpha-Gal and Vector-borne Diseases.
PG  - 470-476
LID - S1471-4922(15)00153-1 [pii]
LID - 10.1016/j.pt.2015.06.016 [doi]
AB  - Vector-borne diseases (VBD) challenge our understanding of emerging diseases. 
      Recently, arthropod vectors have been involved in emerging anaphylactic diseases. 
      In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate 
      Galalpha1-3Galbeta1-(3)4GlcNAc-R (alpha-gal) following a tick bite was associated with 
      allergies to red meat, cetuximab, and gelatin. By contrast, an anti-alpha-gal IgM 
      antibody response was shown to protect against mosquito-borne malaria. Herein, we 
      highlight the interplay between the gut microbiota, vectors, transmitted 
      pathogens, and the regulation of the immune response as a model to understand the 
      protective or allergic effect of alpha-gal. Establishing the source of alpha-gal in 
      arthropod vectors and the immune response to vector bites and transmitted 
      pathogens will be essential for diagnosing, treating, and ultimately preventing 
      these emerging anaphylactic and other vector-borne diseases.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Cabezas-Cruz, Alejandro
AU  - Cabezas-Cruz A
AD  - Center for Infection and Immunity of Lille (CIIL), INSERM U1019 - CNRS UMR 8204, 
      Universite Lille Nord de France, Institut Pasteur de Lille, Lille, France.
FAU - Mateos-Hernandez, Lourdes
AU  - Mateos-Hernandez L
AD  - SaBio. Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      13005 Ciudad Real, Spain.
FAU - Perez-Cruz, Magdiel
AU  - Perez-Cruz M
AD  - Center for Infection and Immunity of Lille (CIIL), INSERM U1019 - CNRS UMR 8204, 
      Universite Lille Nord de France, Institut Pasteur de Lille, Lille, France.
FAU - Valdes, James J
AU  - Valdes JJ
AD  - Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech 
      Republic, 37005 Ceske Budejovice, Czech Republic.
FAU - Mera, Isabel G Fernandez de
AU  - Mera IGF
AD  - SaBio. Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      13005 Ciudad Real, Spain.
FAU - Villar, Margarita
AU  - Villar M
AD  - SaBio. Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      13005 Ciudad Real, Spain.
FAU - de la Fuente, Jose
AU  - de la Fuente J
AD  - SaBio. Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      13005 Ciudad Real, Spain; Department of Veterinary Pathobiology, Center for 
      Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. 
      Electronic address: jose_delafuente@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Trends Parasitol
JT  - Trends in parasitology
JID - 100966034
RN  - 0 (Arthropod Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Arthropod Proteins/*immunology
MH  - Arthropod Vectors/*immunology
MH  - *Disease Vectors
MH  - Host-Parasite Interactions/*immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/immunology
MH  - Th2 Cells/immunology
OTO - NOTNLM
OT  - alpha-gal
OT  - malaria
OT  - tick
OT  - vaccine
OT  - vector-borne diseases
EDAT- 2015/10/05 06:00
MHDA- 2015/12/31 06:00
CRDT- 2015/10/05 06:00
PHST- 2015/04/05 00:00 [received]
PHST- 2015/05/18 00:00 [revised]
PHST- 2015/06/24 00:00 [accepted]
PHST- 2015/10/05 06:00 [entrez]
PHST- 2015/10/05 06:00 [pubmed]
PHST- 2015/12/31 06:00 [medline]
AID - S1471-4922(15)00153-1 [pii]
AID - 10.1016/j.pt.2015.06.016 [doi]
PST - ppublish
SO  - Trends Parasitol. 2015 Oct;31(10):470-476. doi: 10.1016/j.pt.2015.06.016.