PMID- 26433333
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20170808
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 541
DP  - 2016 Jan 15
TI  - Temporal variations in embryotoxicity of Lake Ontario American eel (Anguilla 
      rostrata) extracts to developing Fundulus heteroclitus.
PG  - 765-775
LID - S0048-9697(15)30709-9 [pii]
LID - 10.1016/j.scitotenv.2015.09.049 [doi]
AB  - The recruitment of American eel (Anguilla rostrata) juveniles to Lake Ontario 
      (LO), Canada has declined significantly since the 1980s. To investigate the 
      possible contribution of maternally-transferred persistent organic pollutants 
      (POPs) to this decline, this study measured temporal variations in the toxicity 
      of complex organic mixtures extracted from LO American eels captured in 1988, 
      1998 and 2008 to developing Fundulus heteroclitus exposed by intravitelline (IVi) 
      injection. The 1988 and 1998 eel extracts were most toxic, causing a pattern of 
      sublethal embryotoxic responses similar to those previously reported in F. 
      heteroclitus embryos exposed to single dioxin-like compounds (DLCs): stunted 
      growth, craniofacial deformities, EROD activity induction, and reduced predatory 
      capacities. The potency of extracts declined over time; the only significant 
      effect of the 2008 eel extracts was EROD induction. The chemically-derived 
      TCDD-TEQs of eel extracts, calculated using measured concentrations of some DLCs 
      and their relative potencies for F. heteroclitus, overestimated their potency to 
      induce EROD activity possibly due to interactions among POPs. Other POPs measured 
      in eel extracts (non-dioxin-like PCBs, PBDEs and organochlorinated pesticides) 
      did not appear to be important agonistic contributors to the observed toxicity. 
      The toxicity of the complex mixtures of POPs measured in LO eels may have been 
      underestimated as a result of several factors, including the loss of POPs during 
      extracts preparation and a focus only on short-term effects. Based on the model 
      species examined, our results support the hypothesis that contamination of LO 
      with DLCs may have represented a threat to the American eel population through 
      ecologically-relevant effects such as altered larval prey capture ability. These 
      results prioritize the need to assess early life stage (ELS) toxicity of DLCs in 
      Anguilla species, to investigate long-term effects of complex eel extracts to ELS 
      of fish, and to develop biomarkers for potential effects in eel ELS sampled in 
      the field.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Rigaud, Cyril
AU  - Rigaud C
AD  - Institut des Sciences de la Mer, Universite du Quebec a Rimouski, 310 Allee des 
      Ursulines, Rimouski, Quebec G5L 3A1, Canada; Fisheries and Oceans Canada, Maurice 
      Lamontagne Institute, P.O. Box 1000, Mont-Joli, Quebec G5H 3Z4, Canada. 
      Electronic address: rigaud.cyril@gmail.com.
FAU - Couillard, Catherine M
AU  - Couillard CM
AD  - Fisheries and Oceans Canada, Maurice Lamontagne Institute, P.O. Box 1000, 
      Mont-Joli, Quebec G5H 3Z4, Canada. Electronic address: 
      catherine.couillard@dfo-mpo.gc.ca.
FAU - Pellerin, Jocelyne
AU  - Pellerin J
AD  - Institut des Sciences de la Mer, Universite du Quebec a Rimouski, 310 Allee des 
      Ursulines, Rimouski, Quebec G5L 3A1, Canada.
FAU - Legare, Benoit
AU  - Legare B
AD  - Fisheries and Oceans Canada, Maurice Lamontagne Institute, P.O. Box 1000, 
      Mont-Joli, Quebec G5H 3Z4, Canada.
FAU - Byer, Jonathan D
AU  - Byer JD
AD  - Environment Canada, 867 Lakeshore Road, Burlington, Ontario L7R 4A6, Canada; 
      Queen's University, 99 University Avenue, Kingston, Ontario K7L 3N6, Canada.
FAU - Alaee, Mehran
AU  - Alaee M
AD  - Environment Canada, 867 Lakeshore Road, Burlington, Ontario L7R 4A6, Canada.
FAU - Lebeuf, Michel
AU  - Lebeuf M
AD  - Fisheries and Oceans Canada, Maurice Lamontagne Institute, P.O. Box 1000, 
      Mont-Joli, Quebec G5H 3Z4, Canada.
FAU - Casselman, John M
AU  - Casselman JM
AD  - Queen's University, 99 University Avenue, Kingston, Ontario K7L 3N6, Canada.
FAU - Hodson, Peter V
AU  - Hodson PV
AD  - Queen's University, 99 University Avenue, Kingston, Ontario K7L 3N6, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151002
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Dioxins)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - *Anguilla
MH  - Animals
MH  - Dioxins/toxicity
MH  - Embryo, Nonmammalian/*drug effects
MH  - Environmental Monitoring
MH  - Fundulidae/*embryology
MH  - Halogenated Diphenyl Ethers
MH  - Lakes/chemistry
MH  - Ontario
MH  - Pesticides/toxicity
MH  - Polychlorinated Biphenyls/toxicity
MH  - Polychlorinated Dibenzodioxins/toxicity
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - American eel
OT  - Behavior
OT  - Dioxin
OT  - Embryotoxicity
OT  - Fundulus heteroclitus
OT  - PCB
EDAT- 2015/10/05 06:00
MHDA- 2016/08/23 06:00
CRDT- 2015/10/05 06:00
PHST- 2015/07/19 00:00 [received]
PHST- 2015/09/10 00:00 [revised]
PHST- 2015/09/10 00:00 [accepted]
PHST- 2015/10/05 06:00 [entrez]
PHST- 2015/10/05 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
AID - S0048-9697(15)30709-9 [pii]
AID - 10.1016/j.scitotenv.2015.09.049 [doi]
PST - ppublish
SO  - Sci Total Environ. 2016 Jan 15;541:765-775. doi: 10.1016/j.scitotenv.2015.09.049. 
      Epub 2015 Oct 2.