PMID- 26434101
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20191210
IS  - 0030-6096 (Print)
IS  - 0030-6096 (Linking)
VI  - 61
IP  - 1
DP  - 2015 Jun
TI  - Clinical Characteristics of Late Gadolinium Enhancement in Patients with Cardiac 
      Sarcoidosis.
PG  - 9-17
AB  - BACKGROUND: The presence of cardiac involvement in sarcoidosis, a multisystem 
      granulomatous disease of unknown etiology, is associated with very poor 
      prognosis. Therefore, early detection of cardiac sarcoidosis (C-sar) is very 
      important for effective treatment. Recently, the value of late gadolinium 
      enhancement (LGE) on cardiac magnetic resonance (CMR), which allows visualization 
      of even minute amounts of myocardial damage, has been emphasized in diagnosing 
      C-sar. Although the presence of LGE has been added as a minor criterion for 
      diagnosing C-sar in the most recent Japan Ministry of Health and Welfare (JMHW) 
      guidelines, its clinical utility remains unknown. METHODS: A total of 17 patients 
      with biopsy-proven extracardiac sarcoidosis, who underwent CMR and examinations 
      using a sufficient number of modalities to diagnose or exclude C-sar in 
      accordance with the JMHW diagnostic criteria, were retrospectively enrolled in 
      this study. Among these 17 patients, 7 patients were diagnosed with C-sar and 10 
      with non-C-sar. We investigated the clinical performance of LGE in the detection 
      of cardiac involvement, compared the distribution of LGE with perfusion defects 
      of iodine-123-labeled 15-(p-iodophenyl)-3R,S-methyl pentadecanoic acid (BMIPP) or 
      thallium-201 (201Tl) scintigraphy, and evaluated the prognostic value of LGE on 
      CMR in identifying adverse clinical events. RESULTS: All patients diagnosed with 
      C-sar were positive for LGE and all diagnosed with non-C-sar patients were 
      negative. Evaluation of LGE revealed a broader range of abnormalities than the 
      evaluation of the defects shown by either BMIPP or 201Tl scintigraphy. All 
      adverse events occurred in the C-sar patients with LGE. CONCLUSIONS: This study 
      showed that LGE is useful for the detection of cardiac involvement, and it might 
      be a promising tool for determining the prognosis of patients with biopsy-proven 
      extracardiac sarcoidosis.
FAU - Matsumoto, Kenji
AU  - Matsumoto K
FAU - Ehara, Shoichi
AU  - Ehara S
FAU - Sakaguchi, Mikumo
AU  - Sakaguchi M
FAU - Otsuka, Kenichiro
AU  - Otsuka K
FAU - Hasegawa, Takao
AU  - Hasegawa T
FAU - Shimada, Kenei
AU  - Shimada K
FAU - Yoshiyama, Minoru
AU  - Yoshiyama M
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Japan
TA  - Osaka City Med J
JT  - Osaka city medical journal
JID - 0376413
RN  - 0 (Contrast Media)
RN  - 0 (Fatty Acids)
RN  - 0 (Iodobenzenes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Thallium Radioisotopes)
RN  - 0J7USQ749M (iodofiltic acid)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Cardiomyopathies/diagnostic imaging/*pathology
MH  - *Contrast Media
MH  - Early Diagnosis
MH  - Fatty Acids
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Iodobenzenes
MH  - Japan
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging/methods
MH  - Myocardium/*pathology
MH  - Positron-Emission Tomography
MH  - Predictive Value of Tests
MH  - Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Sarcoidosis/diagnostic imaging/*pathology
MH  - Thallium Radioisotopes
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2015/10/06 06:00
MHDA- 2015/10/27 06:00
CRDT- 2015/10/06 06:00
PHST- 2015/10/06 06:00 [entrez]
PHST- 2015/10/06 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
PST - ppublish
SO  - Osaka City Med J. 2015 Jun;61(1):9-17.