PMID- 26434611
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20151021
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 63
IP  - 41
DP  - 2015 Oct 21
TI  - Cassia tora Seed Extract and Its Active Compound Aurantio-obtusin Inhibit 
      Allergic Responses in IgE-Mediated Mast Cells and Anaphylactic Models.
PG  - 9037-46
LID - 10.1021/acs.jafc.5b03836 [doi]
AB  - Cassia tora seed is widely used due to its various biological properties 
      including anticancer, antidiabetic, and anti-inflammatory effects. However, there 
      has been no report of the effects of C. tora seed extract (CTE) on immunoglobulin 
      E (IgE)-mediated allergic responses. In this research, we demonstrated the 
      effects of CTE and its active compound aurantio-obtusin on IgE-sensitized 
      allergic reactions in mast cells and passive cutaneous anaphylaxis (PCA). CTE and 
      aurantio-obtusin suppressed degranulation, histamine production, and reactive 
      oxygen species generation and inhibited the production and mRNA expression of 
      tumor necrosis factor-alpha and interleukin-4. CTE and aurantio-obtusin also 
      suppressed the prostaglandin E2 production and expression of cyclooxygenase 2. 
      Furthermore, CTE and aurantio-obtusin suppressed IgE-mediated FcepsilonRI signaling 
      such as phosphorylation of Syk, protein kinase Cmu, phospholipase Cgamma, and 
      extracellular signal-regulated kinases. CTE and aurantio-obtusin blocked mast 
      cell-dependent PCA in IgE-mediated mice. These results suggest that CTE and 
      aurantio-obtusin are a beneficial treatment for allergy-related diseases.
FAU - Kim, Myungsuk
AU  - Kim M
AD  - Natural Products Research Center, Korea Institute of Science and Technology 
      (KIST) Gangneung Institute , Gangwon, Korea.
FAU - Lim, Sue Ji
AU  - Lim SJ
AD  - Natural Products Research Center, Korea Institute of Science and Technology 
      (KIST) Gangneung Institute , Gangwon, Korea.
FAU - Lee, Hee-Ju
AU  - Lee HJ
AD  - Natural Products Research Center, Korea Institute of Science and Technology 
      (KIST) Gangneung Institute , Gangwon, Korea.
FAU - Nho, Chu Won
AU  - Nho CW
AD  - Natural Products Research Center, Korea Institute of Science and Technology 
      (KIST) Gangneung Institute , Gangwon, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151013
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anthraquinones)
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (aurantio-obtusin)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anaphylaxis/*drug therapy/immunology
MH  - Animals
MH  - Anthraquinones/*administration & dosage
MH  - Anti-Allergic Agents/*administration & dosage
MH  - Cassia/*chemistry
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Mast Cells/*drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis
MH  - Plant Extracts/*administration & dosage
MH  - Seeds/chemistry
OTO - NOTNLM
OT  - Cassia tora
OT  - IgE-mediated allergic diseases
OT  - RBL-2H3 mast cells
OT  - aurantio-obtusin
EDAT- 2015/10/06 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/10/06 06:00
PHST- 2015/10/06 06:00 [entrez]
PHST- 2015/10/06 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - 10.1021/acs.jafc.5b03836 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2015 Oct 21;63(41):9037-46. doi: 10.1021/acs.jafc.5b03836. 
      Epub 2015 Oct 13.