PMID- 26434802
OWN - NLM
STAT- MEDLINE
DCOM- 20160906
LR  - 20181113
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 124
IP  - Pt A
DP  - 2016 Jan 1
TI  - Disrupted prefrontal activity during emotion processing in complicated grief: An 
      fMRI investigation.
PG  - 968-976
LID - S1053-8119(15)00876-9 [pii]
LID - 10.1016/j.neuroimage.2015.09.054 [doi]
AB  - Complicated Grief, marked by a persistent and intrusive grief lasting beyond the 
      expected period of adaptation, is associated with a relative inability to 
      disengage from idiographic loss-relevant stimuli (O'Connor and Arizmendi, 2014). 
      In other populations, functional magnetic resonance imaging (fMRI) studies 
      investigating the neural networks associated with this bias consistently 
      implicate the anterior cingulate cortex (ACC) during emotion regulation. In the 
      present study, twenty-eight older adults were categorized into three groups based 
      on grief severity: Complicated Grief (n=8), Non-Complicated Grief (n=9), and 
      Nonbereaved, married controls (n=11). Using a block design, all participants 
      completed 8 blocks (20 stimuli per block) of the ecStroop task during fMRI data 
      acquisition. Differences in neural activity during grief-related (as opposed to 
      neutral) stimuli across groups were examined. Those with Complicated Grief showed 
      an absence of increased rostral ACC (rACC) and fronto-cortical recruitment 
      relative to Nonbereaved controls. Activity in the orbitofrontal cortex (x=6, 
      y=54, z=-10) was significantly elevated in the Non-Complicated Grief group when 
      compared to Nonbereaved controls. Post hoc analysis evidenced activity in the 
      dorsal ACC in the Complicated Grief and Nonbereaved groups late in the task. 
      These findings, supported by behavioral data, suggest a relative inability to 
      recruit the regions necessary for successful completion of this emotional task in 
      those with Complicated Grief. This deficit was not observed in recruitment of the 
      orbitofrontal cortex and the rACC during processing of idiographic semantic 
      stimuli in Non-Complicated Grief.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Arizmendi, Brian
AU  - Arizmendi B
AD  - University of Arizona, USA. Electronic address: arizmendi@email.arizona.edu.
FAU - Kaszniak, Alfred W
AU  - Kaszniak AW
AD  - University of Arizona, USA.
FAU - O'Connor, Mary-Frances
AU  - O'Connor MF
AD  - University of Arizona, USA.
LA  - eng
GR  - K01 AG028404/AG/NIA NIH HHS/United States
GR  - K01-AG028404/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151003
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Attention/physiology
MH  - Brain Mapping
MH  - Emotions/*physiology
MH  - Female
MH  - *Grief
MH  - Gyrus Cinguli/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/physiology
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/*physiology
MH  - Recruitment, Neurophysiological/physiology
MH  - Stroop Test
PMC - PMC4668712
MID - NIHMS727740
OTO - NOTNLM
OT  - Attention
OT  - Complicated Grief
OT  - Grief
OT  - Magnetic resonance imaging
OT  - Psychopathology
OT  - ecStroop
EDAT- 2015/10/06 06:00
MHDA- 2016/09/07 06:00
PMCR- 2017/01/01
CRDT- 2015/10/06 06:00
PHST- 2015/01/04 00:00 [received]
PHST- 2015/08/27 00:00 [revised]
PHST- 2015/09/26 00:00 [accepted]
PHST- 2015/10/06 06:00 [entrez]
PHST- 2015/10/06 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - S1053-8119(15)00876-9 [pii]
AID - 10.1016/j.neuroimage.2015.09.054 [doi]
PST - ppublish
SO  - Neuroimage. 2016 Jan 1;124(Pt A):968-976. doi: 10.1016/j.neuroimage.2015.09.054. 
      Epub 2015 Oct 3.