PMID- 26435137
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151005
LR  - 20181113
IS  - 2093-596X (Print)
IS  - 2093-5978 (Electronic)
IS  - 2093-596X (Linking)
VI  - 30
IP  - 3
DP  - 2015 Sep
TI  - Two Cases of Allergy to Insulin in Gestational Diabetes.
PG  - 402-7
LID - 10.3803/EnM.2015.30.3.402 [doi]
AB  - Allergic reaction to insulin is uncommon since the introduction of human 
      recombinant insulin preparations and is more rare in pregnant than non-pregnant 
      females due to altered immune reaction during pregnancy. Herein, we report two 
      cases of allergic reaction to insulin in gestational diabetes that were 
      successfully managed. One case was a 33-year-old female using isophane-neutral 
      protamine Hagedorn human insulin and insulin lispro. She experienced dyspnea, 
      cough, urticaria and itching sensation at the sites of insulin injection 
      immediately after insulin administration. We discontinued insulin therapy and 
      started oral hypoglycemic agents with metformin and glibenclamide. The other case 
      was a 32-year-old female using insulin lispro and insulin detemer. She 
      experienced pruritus and burning sensation and multiple nodules at the sites of 
      insulin injection. We changed the insulin from insulin lispro to insulin aspart. 
      Assessments including immunoglobulin E (IgE), IgG, eosinophil, insulin antibody 
      level and skin biopsy were performed. In the two cases, the symptoms were 
      resolved after changing the insulin to oral agents or other insulin preparations. 
      We report two cases of allergic reaction to human insulin in gestational diabetes 
      due to its rarity.
FAU - Kim, Gi Jun
AU  - Kim GJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Kim, Shin Bum
AU  - Kim SB
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Jo, Seong Il
AU  - Jo SI
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Shin, Jin Kyeong
AU  - Shin JK
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Kwon, Hee Sun
AU  - Kwon HS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Jeong, Heekyung
AU  - Jeong H
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Son, Jang Won
AU  - Son JW
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Lee, Seong Su
AU  - Lee SS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Kim, Sung Rae
AU  - Kim SR
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea.
FAU - Kim, Byung Kee
AU  - Kim BK
AD  - Department of Clinical Pathology, Bucheon St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Bucheon, Korea.
FAU - Yoo, Soon Jib
AU  - Yoo SJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Bucheon, Korea. sjyoo@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20150518
PL  - Korea (South)
TA  - Endocrinol Metab (Seoul)
JT  - Endocrinology and metabolism (Seoul, Korea)
JID - 101554139
PMC - PMC4595367
OTO - NOTNLM
OT  - Diabetes, gestational
OT  - Hypersensitivity, immediate
OT  - Insulin allergy
COIS- CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2015/10/06 06:00
MHDA- 2015/10/06 06:01
PMCR- 2015/09/01
CRDT- 2015/10/06 06:00
PHST- 2014/08/21 00:00 [received]
PHST- 2014/11/15 00:00 [revised]
PHST- 2014/12/30 00:00 [accepted]
PHST- 2015/10/06 06:00 [entrez]
PHST- 2015/10/06 06:00 [pubmed]
PHST- 2015/10/06 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 201509402 [pii]
AID - 10.3803/EnM.2015.30.3.402 [doi]
PST - ppublish
SO  - Endocrinol Metab (Seoul). 2015 Sep;30(3):402-7. doi: 10.3803/EnM.2015.30.3.402. 
      Epub 2015 May 18.