PMID- 26435208
OWN - NLM
STAT- MEDLINE
DCOM- 20160413
LR  - 20191008
IS  - 1873-3735 (Electronic)
IS  - 0165-6147 (Print)
IS  - 0165-6147 (Linking)
VI  - 36
IP  - 10
DP  - 2015 Oct
TI  - Biologic Approaches to Treat Substance-Use Disorders.
PG  - 628-635
LID - S0165-6147(15)00141-8 [pii]
LID - 10.1016/j.tips.2015.07.002 [doi]
AB  - In contrast to traditional pharmacodynamic approaches to treat substance-use 
      disorders (SUDs), the use of biologics (vaccines, monoclonal antibodies, and 
      genetically modified enzymes) is based on a pharmacokinetic principle: reduce the 
      amount of (and, ideally, eliminate) abused drug entering the central nervous 
      system (CNS). Preclinical studies indicate that biologics are effective in both 
      facilitating abstinence and preventing relapse to abused substances ranging from 
      nicotine to heroin. While data are still emerging, the results from multiple 
      clinical trials can best be described as mixed. Nonetheless, these clinical 
      studies have already provided important insights using 'first-generation' tools 
      that may inform the development of effective and commercially viable biologics to 
      treat tobacco-, cocaine-, and methamphetamine-use disorders.
CI  - Published by Elsevier Ltd.
FAU - Skolnick, Phil
AU  - Skolnick P
AD  - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National 
      Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892-9551, 
      USA. Electronic address: phil.skolnick@nih.gov.
LA  - eng
GR  - Z99 DA999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Pharmacol Sci
JT  - Trends in pharmacological sciences
JID - 7906158
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Vaccines)
RN  - EC 3.- (Hydrolases)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - Humans
MH  - Hydrolases/therapeutic use
MH  - Substance-Related Disorders/*drug therapy/immunology
MH  - Vaccines/therapeutic use
PMC - PMC4593975
MID - NIHMS709401
OTO - NOTNLM
OT  - cocaine
OT  - methamphetamine
OT  - monoclonal antibodies
OT  - nicotine
OT  - substance use disorders
OT  - vaccines
EDAT- 2015/10/06 06:00
MHDA- 2016/04/14 06:00
PMCR- 2016/10/01
CRDT- 2015/10/06 06:00
PHST- 2015/06/02 00:00 [received]
PHST- 2015/07/08 00:00 [revised]
PHST- 2015/07/10 00:00 [accepted]
PHST- 2015/10/06 06:00 [entrez]
PHST- 2015/10/06 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - S0165-6147(15)00141-8 [pii]
AID - 10.1016/j.tips.2015.07.002 [doi]
PST - ppublish
SO  - Trends Pharmacol Sci. 2015 Oct;36(10):628-635. doi: 10.1016/j.tips.2015.07.002.