PMID- 26437342
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20181113
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 541
DP  - 2016 Jan 15
TI  - Environmental exposure to manganese in air: Associations with tremor and motor 
      function.
PG  - 646-654
LID - S0048-9697(15)30744-0 [pii]
LID - 10.1016/j.scitotenv.2015.09.084 [doi]
AB  - BACKGROUND: Manganese (Mn) inhalation has been associated with neuropsychological 
      and neurological sequelae in exposed workers. Few environmental epidemiologic 
      studies have examined the potentially neurotoxic effects of Mn exposure in 
      ambient air on motor function and hand tremor in adult community residents. Mn 
      exposed residents were recruited in two Ohio towns: Marietta, a town near a 
      ferro-manganese smelter, and East Liverpool, a town adjacent to a facility 
      processing, crushing, screening, and packaging Mn products. METHODS: Chronic (>/= 
      10 years) exposure to ambient air Mn in adult residents and effects on 
      neuropsychological and neurological outcomes were investigated. Participants from 
      Marietta (n=100) and East Liverpool (n=86) were combined for analyses. AERMOD 
      dispersion modeling of fixed-site outdoor air monitoring data estimated Mn 
      inhalation over a ten year period. Adult Mn-exposed residents' psychomotor 
      ability was assessed using Finger Tapping, Hand Dynamometer, Grooved Pegboard, 
      and the Computerized Adaptive Testing System (CATSYS) Tremor system. Bayesian 
      structural equation modeling was used to assess associations between air-Mn and 
      motor function and tremor. RESULTS: Air-Mn exposure was significantly correlated 
      in bivariate analyses with the tremor test (CATSYS) for intensity, center 
      frequency and harmonic index. The Bayesian path analysis model showed 
      associations of air-Mn with the CATSYS non-dominant center frequency and harmonic 
      index; while the Bayesian structural equation model revealed associations between 
      air-Mn and lower Finger Tapping scores. Household income was significantly 
      associated with motor dysfunction but not with tremor. CONCLUSION: Tremor and 
      motor function were associated with higher exposure to airborne Mn.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Bowler, Rosemarie M
AU  - Bowler RM
AD  - San Francisco State University, Department of Psychology, San Francisco, CA, 
      United States. Electronic address: rbowl@sfsu.edu.
FAU - Beseler, Cheryl L
AU  - Beseler CL
AD  - Colorado State University, Fort Collins, CO, United States.
FAU - Gocheva, Vihra V
AU  - Gocheva VV
AD  - San Francisco State University, Department of Psychology, San Francisco, CA, 
      United States.
FAU - Colledge, Michelle
AU  - Colledge M
AD  - ATSDR, Region 5, Chicago, IL, United States.
FAU - Kornblith, Erica S
AU  - Kornblith ES
AD  - California School of Professional Psychology at Alliant International University, 
      San Francisco, CA, United States.
FAU - Julian, Jaime R
AU  - Julian JR
AD  - U.S. EPA, Region 5, Chicago, IL, United States.
FAU - Kim, Yangho
AU  - Kim Y
AD  - Ulsan University Hospital, University of Ulsan College of Medicine, Department of 
      Occupational and Environmental Medicine, Ulsan, South Korea.
FAU - Bollweg, George
AU  - Bollweg G
AD  - U.S. EPA, Region 5, Chicago, IL, United States.
FAU - Lobdell, Danelle T
AU  - Lobdell DT
AD  - U.S. EPA, National Health and Environmental Effects Research Laboratory, Research 
      Triangle Park, NC, United States.
LA  - eng
GR  - R13 OH009344/OH/NIOSH CDC HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20151002
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Air Pollutants)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
CIN - Sci Total Environ. 2017 Oct 1;595:839-841. PMID: 28411567
MH  - Adult
MH  - Air Pollutants/*analysis
MH  - Air Pollution/*statistics & numerical data
MH  - Bayes Theorem
MH  - Humans
MH  - Inhalation Exposure/*statistics & numerical data
MH  - Manganese/*analysis
MH  - Neuropsychological Tests
MH  - Ohio/epidemiology
MH  - Tremor/chemically induced/*epidemiology
PMC - PMC4803294
MID - NIHMS766998
OID - NLM: HHSPA766998 [Available on 01/15/17]
OTO - NOTNLM
OT  - Adult residents
OT  - Environment
OT  - Manganese
OT  - Neurotoxicity
OT  - Psychomotor
OT  - Tremor
EDAT- 2015/10/06 06:00
MHDA- 2016/08/23 06:00
PMCR- 2017/01/15
CRDT- 2015/10/06 06:00
PHST- 2015/05/29 00:00 [received]
PHST- 2015/08/19 00:00 [revised]
PHST- 2015/09/16 00:00 [accepted]
PHST- 2015/10/06 06:00 [entrez]
PHST- 2015/10/06 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
PHST- 2017/01/15 00:00 [pmc-release]
AID - S0048-9697(15)30744-0 [pii]
AID - 10.1016/j.scitotenv.2015.09.084 [doi]
PST - ppublish
SO  - Sci Total Environ. 2016 Jan 15;541:646-654. doi: 10.1016/j.scitotenv.2015.09.084. 
      Epub 2015 Oct 2.