PMID- 26439642
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20151203
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 6
IP  - 12
DP  - 2015 Dec
TI  - Bile sequestration potential of an edible mineral (clinoptilolite) under 
      simulated digestion of a high-fat meal: an in vitro investigation.
PG  - 3818-27
LID - 10.1039/c5fo00116a [doi]
AB  - Bile, important for cholesterol homeostasis, is a potential target of 
      hypercholesterolemia management. Bile sequestration by orally administered 
      resins, while mostly effective in reducing blood cholesterol, presents several 
      side effects and disadvantages. Thus, widely available natural edible minerals 
      such as clinoptilolite with adsorptive properties offer an alternative for bile 
      sequestration. In an experimental setting mimicking the physiological conditions 
      of digestion/absorption (pH, temperature, and retention times) with a series of 
      assessment methods, scanning electron microscopy-energy dispersion X-ray analysis 
      (SEM-EDX), X-ray diffraction (XRD), Fourier transform infrared analysis (FT-IR), 
      thermogravimetric differential thermal analysis (TG-DTA), and molecular docking 
      modeling, the ability of natural unmodified clinoptilolite to retain bile, while 
      mixed with a simulated high-fat meal, was investigated. Our results demonstrate 
      that clinoptilolite sequesters bile via adsorption of macromicelles at 75.4% 
      efficiency, when the former is administered at a reasonable dose of 4% (w/w) of a 
      meal's weight. This work provides the possibility of clinoptilolite utilization 
      as a bile-sequestering/cholesterol-reducing agent.
FAU - Kristo, Aleksandra S
AU  - Kristo AS
AD  - Istanbul Yeni Yuzyil University, Department of Nutrition and Dietetics, Istanbul, 
      Turkey. as545@cornell.edu.
FAU - Tzanidaki, Garyfallia
AU  - Tzanidaki G
FAU - Lygeros, Andreas
AU  - Lygeros A
FAU - Sikalidis, Angelos K
AU  - Sikalidis AK
LA  - eng
PT  - Journal Article
DEP - 20151006
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Dietary Fats)
RN  - 12173-10-3 (clinoptilolite)
RN  - 1318-02-1 (Zeolites)
SB  - IM
MH  - Adsorption
MH  - Bile/*metabolism
MH  - *Dietary Fats
MH  - *Digestion
MH  - Hydrogen-Ion Concentration
MH  - Microscopy, Electron, Scanning
MH  - Molecular Docking Simulation
MH  - Spectroscopy, Fourier Transform Infrared
MH  - X-Ray Diffraction
MH  - Zeolites/*pharmacology
EDAT- 2015/10/07 06:00
MHDA- 2016/09/23 06:00
CRDT- 2015/10/07 06:00
PHST- 2015/10/07 06:00 [entrez]
PHST- 2015/10/07 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - 10.1039/c5fo00116a [doi]
PST - ppublish
SO  - Food Funct. 2015 Dec;6(12):3818-27. doi: 10.1039/c5fo00116a. Epub 2015 Oct 6.