PMID- 26440004
OWN - NLM
STAT- MEDLINE
DCOM- 20160802
LR  - 20211203
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 93
IP  - 7
DP  - 2015 Jul
TI  - Dietary chromium methionine supplementation could alleviate immunosuppressive 
      effects of heat stress in broiler chicks.
PG  - 3355-63
LID - 10.2527/jas.2014-8807 [doi]
AB  - The present study was conducted to investigate the effects of dietary 
      supplementation of chromium methionine (CrMet) on performance, immune responses, 
      and stress status of broiler chicks subjected to heat-stress conditions. A total 
      of 450 day-old Ross 308 broiler chicks were randomly distributed between 5 
      replicate pens (15 birds each) of 6 experimental treatments according to a 2 x 3 
      factorial arrangement of treatments including 2 temperature conditions 
      (thermoneutral and heat stress) and 3 supplemental Cr levels (0, 500, and 1,000 
      mug/kg as CrMet). For induction of heat stress, the house temperature was set at 
      35 +/- 2 degrees C from 15 to 42 d of age. Results showed that the chicks subjected to 
      heat-stress condition had lower (P < 0.01) feed intake, BW gain, and deteriorated 
      (P < 0.05) feed conversion values compared with those kept in the thermoneutral 
      house. Dietary supplementation with CrMet increased (P < 0.01) feed intake and 
      improved (P < 0.01) weight gain and feed efficiency. There were significant Cr 
      level x temperature interactions, so that inclusion of CrMet into the diets was 
      more effective in heat-stressed chicks. Exposure to heat stress suppressed (P < 
      0.01) cutaneous hypersensivity response to phytohemagglutinin-P injection at 30 d 
      of age, and dietary supplementation of 500 mug Cr/kg induced (P < 0.05) this 
      response, with the greater impacts in heat-stressed chicks, resulting in a 
      significant (P < 0.01) Cr x temperature interaction. Antibody responses against 
      Newcastle and infectious bronchitis disease viruses were diminished (P < 0.01) in 
      heat-stressed chicks. Dietary inclusion of CrMet improved (P < 0.05) antibody 
      responses to different immunostimulants, and this effect was more pronounced in 
      heat-stressed chicks. Exposure to heat stress caused a significant (P < 0.05) 
      decrease in the proportion of helper (CD4+) T lymphocytes and increased cytotoxic 
      (CD8+) T lymphocytes, resulting in a decreased (P < 0.01) CD4+ to CD8+ ratio in 
      peripheral blood circulation. Supplementation of CrMet to heat-stressed chicks 
      modulated (P < 0.01) plasma corticosterone level. The present findings indicate 
      that dietary CrMet supplementation could alleviate heat-stress-induced growth 
      retardation in broiler chicks. Moreover, supplemental CrMet modulated suppressive 
      effects of heat stress on cellular and humoral immune responses.
FAU - Jahanian, R
AU  - Jahanian R
FAU - Rasouli, E
AU  - Rasouli E
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0R0008Q3JB (Chromium)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Animals
MH  - Chickens/physiology
MH  - Chromium/administration & dosage/*pharmacology
MH  - Diet/veterinary
MH  - *Dietary Supplements
MH  - Heat Stress Disorders/blood/*veterinary
MH  - Hot Temperature/adverse effects
MH  - Immunosuppression Therapy/*veterinary
MH  - Methionine/administration & dosage/*pharmacology
MH  - Poultry Diseases/blood/*prevention & control
EDAT- 2015/10/07 06:00
MHDA- 2016/08/03 06:00
CRDT- 2015/10/07 06:00
PHST- 2015/10/07 06:00 [entrez]
PHST- 2015/10/07 06:00 [pubmed]
PHST- 2016/08/03 06:00 [medline]
AID - 10.2527/jas.2014-8807 [doi]
PST - ppublish
SO  - J Anim Sci. 2015 Jul;93(7):3355-63. doi: 10.2527/jas.2014-8807.