PMID- 26440545
OWN - NLM
STAT- MEDLINE
DCOM- 20160728
LR  - 20181202
IS  - 1879-3363 (Electronic)
IS  - 0025-326X (Print)
IS  - 0025-326X (Linking)
VI  - 100
IP  - 1
DP  - 2015 Nov 15
TI  - Variation in bioaccumulation of persistent organic pollutants based on 
      octanol-air partitioning: Influence of respiratory elimination in marine species.
PG  - 122-127
LID - S0025-326X(15)30038-2 [pii]
LID - 10.1016/j.marpolbul.2015.09.020 [doi]
AB  - Risk assessments of persistent organic pollutants (POPs) are often based on 
      octanol-water (KOW) partitioning dynamics and may not adequately reflect 
      bioaccumulation in air-breathing organisms. It has been suggested that compounds 
      with low KOW and high octanol-air partitioning (KOA) coefficients have the 
      potential to bioaccumulate in air-breathing organisms, including marine mammals. 
      Here we evaluate differences in concentrations of POPs for two trophically 
      matched Arctic species, spotted seal (Phoca largha) and sheefish (Stenodus 
      leucichthys). We compared concentrations of 108 POPs in matched tissues (liver 
      and muscle) across three ranges of KOW. We found a significant positive 
      correlation between POP concentration and log KOA in spotted seal tissues for low 
      log KOW compounds (log KOW <5.5, p<0.05). This provides further evidence for 
      empirical models and observed bioaccumulation patterns in air-breathing 
      organisms, and highlights the potential for bioaccumulation of these compounds in 
      Arctic marine mammals.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Moses, Sara K
AU  - Moses SK
AD  - Biological Services Division, Environmental Section, Great Lakes Indian Fish and 
      Wildlife Commission, 72682 Maple Street, Odanah, WI 54861, USA.
FAU - Harley, John R
AU  - Harley JR
AD  - Department of Chemistry and Biochemistry, University of Alaska Fairbanks, 900 
      Yukon Drive, Fairbanks, AK 99775, USA. Electronic address: 
      john.harley@alaska.edu.
FAU - Lieske, Camilla L
AU  - Lieske CL
AD  - Institute of Arctic Biology, University of Alaska Fairbanks, 905 N Koyukuk Dr, 
      Fairbanks, AK 99775-7220, USA.
FAU - Muir, Derek C G
AU  - Muir DCG
AD  - Aquatic Ecosystem Protection Research Division, Environment Canada, Burlington, 
      ON L7R 4A6, Canada.
FAU - Whiting, Alex V
AU  - Whiting AV
AD  - Native Village of Kotzebue, Kotzebue, AK 99752, USA.
FAU - O'Hara, Todd M
AU  - O'Hara TM
AD  - Department of Veterinary Medicine, University of Alaska Fairbanks, 901 Koyukuk 
      Drive, Fairbanks, AK 99775, USA.
LA  - eng
GR  - P20 RR016430/RR/NCRR NIH HHS/United States
GR  - P20 RR016466/RR/NCRR NIH HHS/United States
GR  - 5P20RR016430/RR/NCRR NIH HHS/United States
GR  - 5P20RR016466/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151004
PL  - England
TA  - Mar Pollut Bull
JT  - Marine pollution bulletin
JID - 0260231
RN  - 0 (Octanols)
RN  - 0 (Organic Chemicals)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Air
MH  - Animals
MH  - Arctic Regions
MH  - Food Chain
MH  - Liver/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - Octanols/chemistry
MH  - Organic Chemicals/chemistry/*pharmacokinetics
MH  - Phoca/*metabolism
MH  - Risk Assessment
MH  - Salmonidae/*metabolism
MH  - Tissue Distribution
MH  - Water Pollutants, Chemical/chemistry/*pharmacokinetics
PMC - PMC4679492
MID - NIHMS728524
OTO - NOTNLM
OT  - Arctic
OT  - Bioaccumulation
OT  - Marine mammals
OT  - OCs
OT  - POPs
EDAT- 2015/10/07 06:00
MHDA- 2016/07/29 06:00
PMCR- 2016/11/15
CRDT- 2015/10/07 06:00
PHST- 2015/07/07 00:00 [received]
PHST- 2015/09/09 00:00 [revised]
PHST- 2015/09/15 00:00 [accepted]
PHST- 2015/10/07 06:00 [entrez]
PHST- 2015/10/07 06:00 [pubmed]
PHST- 2016/07/29 06:00 [medline]
PHST- 2016/11/15 00:00 [pmc-release]
AID - S0025-326X(15)30038-2 [pii]
AID - 10.1016/j.marpolbul.2015.09.020 [doi]
PST - ppublish
SO  - Mar Pollut Bull. 2015 Nov 15;100(1):122-127. doi: 
      10.1016/j.marpolbul.2015.09.020. Epub 2015 Oct 4.