PMID- 26441515
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151007
LR  - 20200930
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 8
DP  - 2015
TI  - Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, attenuates 
      postoperative cognitive dysfunction in aging mice.
PG  - 52
LID - 10.3389/fnmol.2015.00052 [doi]
LID - 52
AB  - Postoperative cognitive dysfunction (POCD) is a recognized clinical entity 
      characterized with cognitive deficits after anesthesia and surgery, especially in 
      aged patients. Previous studies have shown that histone acetylation plays a key 
      role in hippocampal synaptic plasticity and memory formation. However, its role 
      in POCD remains to be determined. Here, we show that suberoylanilide hydroxamic 
      acid (SAHA), a histone deacetylase inhibitor, attenuates POCD in aging Mice. 
      After exposed to the laparotomy, a surgical procedure involving an incision into 
      abdominal walls to examine the abdominal organs, 16- but not 3-month old male 
      C57BL/6 mice developed obvious cognitive impairments in the test of long-term 
      contextual fear conditioning. Intracerebroventricular (i.c.v.) injection of SAHA 
      at the dose of (20 mug/2 mul) 3 h before and daily after the laparotomy restored 
      the laparotomy-induced reduction of hippocampal acetyl-H3 and acetyl-H4 levels 
      and significantly attenuated the hippocampus-dependent long-term memory (LTM) 
      impairments in 16-month old mice. SAHA also reduced the expression of cleaved 
      caspase-3, inducible nitric oxide synthase (iNOS) and N-methyl-D-aspartate (NMDA) 
      receptor-calcium/calmodulin dependent kinase II (CaMKII) pathway, and increased 
      the expression of brain-derived neurotrophic factor (BDNF), synapsin 1, and 
      postsynaptic density 95 (PSD95). Taken together, our data suggest that the 
      decrease of histone acetylation contributes to POCD and may serve as a target to 
      improve the neurological outcome of POCD.
FAU - Jia, Min
AU  - Jia M
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing, China.
FAU - Liu, Wen-Xue
AU  - Liu WX
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing, China.
FAU - Sun, He-Liang
AU  - Sun HL
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing, China.
FAU - Chang, Yan-Qing
AU  - Chang YQ
AD  - Institute of Aging Research, School of Medicine, Hangzhou Normal University 
      Hangzhou, China.
FAU - Yang, Jiao-Jiao
AU  - Yang JJ
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing, China ; Jiangsu Province Key Laboratory of Anesthesiology, 
      Xuzhou Medical College Xuzhou, China ; Jiangsu Province Key Laboratory of 
      Anesthesia and Analgesia Application Technology Xuzhou, China.
FAU - Ji, Mu-Huo
AU  - Ji MH
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing, China.
FAU - Yang, Jian-Jun
AU  - Yang JJ
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing, China ; Jiangsu Province Key Laboratory of Anesthesiology, 
      Xuzhou Medical College Xuzhou, China ; Jiangsu Province Key Laboratory of 
      Anesthesia and Analgesia Application Technology Xuzhou, China.
FAU - Feng, Chen-Zhuo
AU  - Feng CZ
AD  - Institute of Aging Research, School of Medicine, Hangzhou Normal University 
      Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20150923
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC4585136
OTO - NOTNLM
OT  - aging
OT  - histone acetylation
OT  - neuroapoptosis
OT  - postoperative cognitive dysfunction
OT  - synaptic plasticity
EDAT- 2015/10/07 06:00
MHDA- 2015/10/07 06:01
PMCR- 2015/01/01
CRDT- 2015/10/07 06:00
PHST- 2015/06/25 00:00 [received]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/10/07 06:00 [entrez]
PHST- 2015/10/07 06:00 [pubmed]
PHST- 2015/10/07 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2015.00052 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2015 Sep 23;8:52. doi: 10.3389/fnmol.2015.00052. eCollection 
      2015.