PMID- 26441525
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151007
LR  - 20220321
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 9
DP  - 2015
TI  - Breaking boundaries-coagulation and fibrinolysis at the neurovascular interface.
PG  - 354
LID - 10.3389/fncel.2015.00354 [doi]
LID - 354
AB  - Blood proteins at the neurovascular unit (NVU) are emerging as important 
      molecular determinants of communication between the brain and the immune system. 
      Over the past two decades, roles for the plasminogen activation (PA)/plasmin 
      system in fibrinolysis have been extended from peripheral dissolution of blood 
      clots to the regulation of central nervous system (CNS) functions in physiology 
      and disease. In this review, we discuss how fibrin and its proteolytic 
      degradation affect neuroinflammatory, degenerative and repair processes. In 
      particular, we focus on novel functions of fibrin-the final product of the 
      coagulation cascade and the main substrate of plasmin-in the activation of immune 
      responses and trafficking of immune cells into the brain. We also comment on the 
      suitability of the coagulation and fibrinolytic systems as potential biomarkers 
      and drug targets in diseases, such as multiple sclerosis (MS), Alzheimer's 
      disease (AD) and stroke. Studying coagulation and fibrinolysis as major molecular 
      pathways that regulate cellular functions at the NVU has the potential to lead to 
      the development of novel strategies for the detection and treatment of neurologic 
      diseases.
FAU - Bardehle, Sophia
AU  - Bardehle S
AD  - Gladstone Institute of Neurological Disease, University of California, San 
      Francisco San Francisco, CA, USA.
FAU - Rafalski, Victoria A
AU  - Rafalski VA
AD  - Gladstone Institute of Neurological Disease, University of California, San 
      Francisco San Francisco, CA, USA.
FAU - Akassoglou, Katerina
AU  - Akassoglou K
AD  - Gladstone Institute of Neurological Disease, University of California, San 
      Francisco San Francisco, CA, USA ; Department of Neurology, University of 
      California, San Francisco San Francisco, CA, USA.
LA  - eng
GR  - R01 NS051470/NS/NINDS NIH HHS/United States
GR  - R01 NS052189/NS/NINDS NIH HHS/United States
GR  - R21 NS082976/NS/NINDS NIH HHS/United States
GR  - T32 AI007334/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20150916
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC4584986
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - autoimmunity
OT  - blood-brain barrier
OT  - fibrinogen
OT  - microglia
OT  - multiple sclerosis
OT  - neurodegeneration
OT  - neuroinflammation
EDAT- 2015/10/07 06:00
MHDA- 2015/10/07 06:01
PMCR- 2015/01/01
CRDT- 2015/10/07 06:00
PHST- 2015/07/30 00:00 [received]
PHST- 2015/08/24 00:00 [accepted]
PHST- 2015/10/07 06:00 [entrez]
PHST- 2015/10/07 06:00 [pubmed]
PHST- 2015/10/07 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2015.00354 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2015 Sep 16;9:354. doi: 10.3389/fncel.2015.00354. 
      eCollection 2015.