PMID- 26442458
OWN - NLM
STAT- MEDLINE
DCOM- 20160810
LR  - 20220318
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 38
IP  - 10
DP  - 2015 Oct
TI  - Correlation of the New York Heart Association Classification and the 6-Minute 
      Walk Distance: A Systematic Review.
PG  - 621-8
LID - 10.1002/clc.22468 [doi]
AB  - BACKGROUND: Functional status assessment is the cornerstone of heart failure 
      management and trials. The New York Heart Association (NYHA) classification and 
      6-minute walk distance (6MWD) are commonly used tools; however, the correlation 
      between them is not well understood. HYPOTHESIS: We hypothesised that the 
      relationship between the NYHA classification and 6MWD might vary across studies. 
      METHODS: A systematic literature search was performed to identify all studies 
      reporting both NYHA class and 6MWD. Two reviewers independently assessed study 
      eligibility and extracted data. Thirty-seven studies involving 5678 patients were 
      included. RESULTS: There was significant heterogeneity across studies in 6MWD 
      within all NYHA classes: I (n = 16, Q = 934.2; P < 0.001), II (n = 25, 
      Q = 1658.3; P < 0.001), III (n = 30, Q = 1020.1; P < 0.001), and IV (n = 6, 
      Q = 335.5; P < 0.001). There was no significant difference in average 6MWD 
      between NYHA I and II (420 m vs 393 m; P = 0.416). There was a significant 
      difference in average 6MWD between NYHA II and III (393 m vs 321 m; P = 0.014) 
      and III and IV (321 m vs 224 m; P = 0.027). This remained significant after 
      adjusting for region of study, age, and sex. CONCLUSIONS: Although there is an 
      inverse correlation between NYHA II-IV and 6MWD, there is significant 
      heterogeneity across studies in 6MWD within each NYHA class and overlap in 6MWD 
      between NYHA I and II. The NYHA classification performs well in more symptomatic 
      patients (NYHA III/IV) but less so in asymptomatic/mildly symptomatic patients 
      (NYHA I/II). Nonetheless, the NYHA classification is an easily applied first-line 
      tool in everyday clinical practice, but its potential subjectivity should be 
      considered when performing comparisons across studies.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Yap, Jonathan
AU  - Yap J
AD  - Department of Cardiology, National Heart Centre Singapore, Singapore.
FAU - Lim, Fang Yi
AU  - Lim FY
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
FAU - Gao, Fei
AU  - Gao F
AD  - Department of Cardiology, National Heart Centre Singapore, Singapore.
AD  - Duke-NUS Graduate Medical School, Singapore.
FAU - Teo, Ling Li
AU  - Teo LL
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
FAU - Lam, Carolyn Su Ping
AU  - Lam CS
AD  - Department of Cardiology, National Heart Centre Singapore, Singapore.
AD  - Cardiovascular Research Institute, National University of Singapore, Singapore.
FAU - Yeo, Khung Keong
AU  - Yeo KK
AD  - Department of Cardiology, National Heart Centre Singapore, Singapore.
AD  - Duke-NUS Graduate Medical School, Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20151007
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Exercise Test/*methods
MH  - *Exercise Tolerance
MH  - Female
MH  - Heart Failure/classification/*diagnosis/physiopathology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Sex Factors
MH  - Time Factors
MH  - *Walking
PMC - PMC6490728
EDAT- 2015/10/08 06:00
MHDA- 2016/08/11 06:00
PMCR- 2015/10/07
CRDT- 2015/10/08 06:00
PHST- 2015/04/28 00:00 [received]
PHST- 2015/08/19 00:00 [revised]
PHST- 2015/10/08 06:00 [entrez]
PHST- 2015/10/08 06:00 [pubmed]
PHST- 2016/08/11 06:00 [medline]
PHST- 2015/10/07 00:00 [pmc-release]
AID - CLC22468 [pii]
AID - 10.1002/clc.22468 [doi]
PST - ppublish
SO  - Clin Cardiol. 2015 Oct;38(10):621-8. doi: 10.1002/clc.22468. Epub 2015 Oct 7.