PMID- 26444719
OWN - NLM
STAT- MEDLINE
DCOM- 20160105
LR  - 20151008
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 11
DP  - 2015 Oct
TI  - Foveal Photoreceptor Deformation as a Significant Predictor of Postoperative 
      Visual Outcome in Idiopathic Epiretinal Membrane Surgery.
PG  - 6387-93
LID - 10.1167/iovs.15-16679 [doi]
AB  - PURPOSE: The purpose of this study was to determine whether the outer nuclear 
      layer (ONL) deformation detected by spectral-domain optical coherence tomography 
      (SD-OCT) is correlated with visual acuity before and after surgery in patients 
      with idiopathic epiretinal membrane (ERM). METHODS: Forty-four eyes of 44 
      patients who underwent vitreous surgery for treatment of ERM were included. All 
      patients underwent comprehensive ophthalmologic evaluations including measurement 
      of best corrected visual acuity (BCVA) and SD-OCT before and after surgery. The 
      central foveal thickness (CFT), foveal ONL thickness, juxtafoveal ONL plus outer 
      plexiform layer (OPL) thickness, photoreceptor outer segment thickness, and size 
      of the disrupted interdigitation zone (IZ) line were measured. We defined the 
      "photoreceptor deformation index" (PDI) as the ratio of foveal ONL thickness to 
      the juxtafoveal ONL plus OPL thickness. RESULTS: Multiple regression analysis 
      showed that the only significant predictor of preoperative mean logarithm of the 
      minimum angle of resolution (logMAR) BCVA was preoperative CFT (P < 0.0001). 
      Preoperative PDI (P < 0.0001) and disrupted IZ diameter (P = 0.0242) were 
      positively correlated with logMAR at 3 months after surgery. PDI (P < 0.0001) and 
      disrupted IZ diameter (P = 0.0351) were also positively correlated with logMAR 
      BCVA at 6 months after surgery. The only significant predictor of logMAR at 12 
      months after surgery was preoperative PDI (P < 0.0001). CONCLUSIONS: Preoperative 
      PDI was most significantly correlated with postoperative BCVA. These results 
      suggest that PDI is a novel parameter predicting visual outcome after surgery in 
      eyes with ERM.
FAU - Hosoda, Yoshikatsu
AU  - Hosoda Y
AD  - Department of Ophthalmology and Visual Sciences Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Ooto, Sotaro
AU  - Ooto S
AD  - Department of Ophthalmology and Visual Sciences Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Hangai, Masanori
AU  - Hangai M
AD  - Department of Ophthalmology and Visual Sciences Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan 2Department of Ophthalmology, Saitama Medical 
      School, Moroyama, Iruma, Saitama, Japan.
FAU - Oishi, Akio
AU  - Oishi A
AD  - Department of Ophthalmology and Visual Sciences Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
AD  - Department of Ophthalmology and Visual Sciences Kyoto University Graduate School 
      of Medicine, Sakyo-ku, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Epiretinal Membrane/pathology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Male
MH  - Postoperative Period
MH  - Retinal Photoreceptor Cell Inner Segment/*pathology
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
MH  - *Vitrectomy
EDAT- 2015/10/09 06:00
MHDA- 2016/01/06 06:00
CRDT- 2015/10/08 06:00
PHST- 2015/10/08 06:00 [entrez]
PHST- 2015/10/09 06:00 [pubmed]
PHST- 2016/01/06 06:00 [medline]
AID - 2455922 [pii]
AID - 10.1167/iovs.15-16679 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6387-93. doi: 10.1167/iovs.15-16679.