PMID- 26445016
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20161230
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 60
IP  - 12
DP  - 2015 Dec
TI  - Interleukin-1 receptor antagonist gene polymorphism, adverse pregnancy outcome 
      and periodontitis in Turkish women.
PG  - 1777-83
LID - S0003-9969(15)30045-5 [pii]
LID - 10.1016/j.archoralbio.2015.09.013 [doi]
AB  - OBJECTIVE: The aim of this study was to determine associations between 
      interleukin (IL)-1A (+4845), IL-1B (+3954), and IL-1 receptor antagonist (RN) 
      variable number tandem repeat polymorphisms and adverse pregnancy outcomes and 
      periodontitis in a Turkish women. DESIGN: A total of 156 patients, including 64 
      women with normal birth outcome (NB) and 92 women with preterm/low birth weight 
      outcome (PLBW) were included in this case-control study. Within 24h after labor, 
      maternal demographic characteristics and clinical periodontal parameters were 
      recorded. The distribution and genotype frequencies of IL-1 were analyzed with 
      polymerase chain reaction-restriction fragment length polymorphism assay. 
      Statistical analyses were carried out for clinical periodontal parameters, 
      genotype frequencies, and to identify explanatory variables for PLBW. RESULTS: 
      PLBW was associated with maternal age (p<0.05), irregular prenatal care 
      (p<0.001), previous PLBW (p<0.05), and antibiotic use during pregnancy (p<0.05). 
      Measurements of probing depth and clinical attachment level (CAL) were 
      significantly higher in the PLBW group than in the NB group (p<0.001). PLBW was 
      associated with IL-1RN allele 2 (p<0.001). Moreover, stepwise logistic regression 
      analysis showed that CAL (OR 1.39, 95% CI: 1.04-1.85) and IL-1RN polymorphism (OR 
      7.92, 95% CI: 2.76-22.79), previous PLBW (OR 5.01, 95% CI: 1.08-23.17), age (OR 
      1.22, 95% CI: 1.04-1.44) were predictors found to increase the risk of PLBW 
      (p<0.05). There was a negative association between PLBW and regular prenatal 
      care, total number of births, use an antibiotic during pregnancy period (p<0.05). 
      CONCLUSION: Our study showed that, IL-1RN allele 2, periodontal disease 
      characterized with clinical attachment loss, previous PLBW and age could be an 
      important risk factors for PLBW.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Kayar, Nezahat Arzu
AU  - Kayar NA
AD  - The Ministry Health of Turkey, Oral and Dental Health Center, Antalya, Turkey.
FAU - Alptekin, Nilgun Ozlem
AU  - Alptekin NO
AD  - Baskent University, Faculty of Dentistry, Department of Periodontology, Ankara, 
      Turkey. Electronic address: noalptekin@baskent.edu.tr.
FAU - Erdal, Mehmet Emin
AU  - Erdal ME
AD  - Mersin University, Faculty of Medicine, Department of Medical Biology and 
      Genetics, Mersin, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150921
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Interleukin 1 Receptor Antagonist Protein/*genetics
MH  - Periodontitis/*genetics
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Pregnancy
MH  - Pregnancy Outcome
OTO - NOTNLM
OT  - Adverse pregnancy outcomes
OT  - Interleukin-1 receptor antagonist variable number tandem repeat polymorphisms
OT  - Interleukin-1A (+4845)
OT  - Interleukin-1B (+3954)
OT  - Periodontitis
EDAT- 2015/10/08 06:00
MHDA- 2016/09/13 06:00
CRDT- 2015/10/08 06:00
PHST- 2014/10/10 00:00 [received]
PHST- 2015/09/14 00:00 [revised]
PHST- 2015/09/16 00:00 [accepted]
PHST- 2015/10/08 06:00 [entrez]
PHST- 2015/10/08 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0003-9969(15)30045-5 [pii]
AID - 10.1016/j.archoralbio.2015.09.013 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2015 Dec;60(12):1777-83. doi: 10.1016/j.archoralbio.2015.09.013. 
      Epub 2015 Sep 21.