PMID- 26445106 OWN - NLM STAT- MEDLINE DCOM- 20160711 LR - 20181113 IS - 1756-8722 (Electronic) IS - 1756-8722 (Linking) VI - 8 DP - 2015 Oct 6 TI - Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation. PG - 107 LID - 10.1186/s13045-015-0207-4 [doi] LID - 107 AB - BACKGROUND: In the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease (GVHD) and of nonrelapse mortality (NRM). The aim of the current analysis was to compare transplantation outcomes in male patients given female unrelated cord blood (UCB) versus other gender combinations. PATIENTS AND METHODS: Data from 552 consecutive patients with acute myeloid leukemia (AML) given a single UCB transplantation between 2000 and 2014 were included. RESULTS: In comparison with other gender combination, male patients given female UCB (n = 131) had a trend for a higher incidence of grades II-IV acute GVHD (33 versus 25 %, P = 0.08), a trend for a higher incidence of NRM (41 versus 33 %, P = 0.06), and a lower leukemia-free (LFS, 30 versus 41 %, P = 0.01) and overall survival (OS, 33 versus 45 %, P = 0.008). In multivariate analyses, taking into consideration all patients for which data on HLA-matching and cell dose transplanted were fully available (n = 363), male patients transplanted with a female UCB had a trend for a higher incidence of grade III-IV acute GVHD (hazard ratio (HR) = 2.0, P = 0.06), a trend for a higher NRM (HR = 1.5, P = 0.06), and a worse LFS (HR = 1.4, P = 0.04) and OS (HR = 1.3, P = 0.06). CONCLUSIONS: Our data suggest that male patients transplanted with female UCB might have higher risk of acute GVHD and of NRM leading to worse LFS and OS. These results should be confirmed in other large cohorts of patients before used for determining the choice of an UCB unit. FAU - Baron, Frederic AU - Baron F AD - Department of Hematology, University of Liege, CHU Sart-Tilman, 4000, Liege, Belgium. f.baron@ulg.ac.be. FAU - Labopin, Myriam AU - Labopin M AD - EBMT Paris Office, Hospital Saint Antoine, Paris, France. myriam.labopin@upmc.fr. FAU - Ruggeri, Annalisa AU - Ruggeri A AD - Eurocord, Hospital Saint Louis, AP-HP, and IUH University Paris VII, Paris, France. annalisa.ruggeri@sat.aphp.fr. AD - AP-HP, Hematologie Clinique et Therapie Cellulaire, Hopital Saint-Antoine, Paris, France. annalisa.ruggeri@sat.aphp.fr. FAU - Mohty, Mohamad AU - Mohty M AD - AP-HP, Hematologie Clinique et Therapie Cellulaire, Hopital Saint-Antoine, Paris, France. mohamad.mohty@inserm.fr. FAU - Sanz, Guillermo AU - Sanz G AD - Hospital Universitario La Fe - Servicio de Hematologia, Valencia, Spain. sanz_gui@gva.es. FAU - Milpied, Noel AU - Milpied N AD - CHU Bordeaux - Hopital Haut-leveque, Pessac, France. noel.milpied@chu-bordeaux.fr. FAU - Bacigalupo, Andrea AU - Bacigalupo A AD - Department of Haematology II, Ospedale San Martino, Genova, Italy. andrea.bacigalupo@hsanmartino.it. FAU - Rambaldi, Alessandro AU - Rambaldi A AD - Azienda Ospedaliera Papa Giovanni XXIII-Hematology and Bone Marrow Transplant Unit, Bergamo, Italy. arambaldi@hpg23.it. FAU - Bonifazi, Francesca AU - Bonifazi F AD - Institute of Hematology and Medical, Oncology L and A Seragnoli, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy. francesca.bonifazi@unibo.it. FAU - Bosi, Alberto AU - Bosi A AD - BMT Unit Department of Hematology, Ospedale di Careggi, Firenze, Italy. alberto.bosi@unifi.it. FAU - Sierra, Jorge AU - Sierra J AD - Hematology Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain. JSierra@santpau.cat. FAU - Yakoub-Agha, Ibrahim AU - Yakoub-Agha I AD - Hopital HURIEZ - UAM allo-CSH - CHRU, Lille, France. i-yakoub-agha@orange.fr. FAU - Santasusana, Josep Maria Ribera AU - Santasusana JM AD - ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras Research Institute, Barcelona, Spain. jribera@iconcologia.net. FAU - Gluckman, Eliane AU - Gluckman E AD - Eurocord, Hospital Saint Louis, AP-HP, and IUH University Paris VII, France Monacord, Centre Scientifique de Monaco, Monaco, Monaco. eliane.gluckman@sls.aphp.fr. FAU - Nagler, Arnon AU - Nagler A AD - EBMT Paris Office, Hospital Saint Antoine, Paris, France. Arnon.Nagler@sheba.health.gov.il. AD - Division of Hematology and Bone Marrow Transplantation, The Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel. Arnon.Nagler@sheba.health.gov.il. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20151006 PL - England TA - J Hematol Oncol JT - Journal of hematology & oncology JID - 101468937 SB - IM MH - Acute Disease MH - Adolescent MH - Adult MH - Aged MH - *Blood Donors MH - Cord Blood Stem Cell Transplantation/adverse effects/*methods/mortality MH - Europe/epidemiology MH - Female MH - Graft vs Host Disease/*diagnosis/epidemiology/etiology MH - Humans MH - Incidence MH - Leukemia, Myeloid/mortality/*therapy MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Retrospective Studies MH - Risk Factors MH - Sex Factors MH - Survival Analysis MH - Survival Rate MH - Young Adult PMC - PMC4594748 EDAT- 2015/10/09 06:00 MHDA- 2016/07/12 06:00 PMCR- 2015/10/06 CRDT- 2015/10/08 06:00 PHST- 2015/07/16 00:00 [received] PHST- 2015/09/28 00:00 [accepted] PHST- 2015/10/08 06:00 [entrez] PHST- 2015/10/09 06:00 [pubmed] PHST- 2016/07/12 06:00 [medline] PHST- 2015/10/06 00:00 [pmc-release] AID - 10.1186/s13045-015-0207-4 [pii] AID - 207 [pii] AID - 10.1186/s13045-015-0207-4 [doi] PST - epublish SO - J Hematol Oncol. 2015 Oct 6;8:107. doi: 10.1186/s13045-015-0207-4.