PMID- 26445610
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151008
LR  - 20220419
IS  - 1759-7706 (Print)
IS  - 1759-7714 (Electronic)
IS  - 1759-7706 (Linking)
VI  - 6
IP  - 5
DP  - 2015 Sep
TI  - Human leukocyte antigen (HLA)-G gene polymorphism in patients with non-small cell 
      lung cancer.
PG  - 613-9
LID - 10.1111/1759-7714.12232 [doi]
AB  - BACKGROUND: Lung cancer represents the highest morbidity and mortality caused by 
      neoplasms in the world; therefore researchers continue to search for new tools to 
      diagnose and treat the disease. The aim of the study was to establish the role of 
      single nucleotide polymorphisms (SNP) in the promoter region of the human 
      leukocyte antigen (HLA)-G gene in patients with non-small cell lung cancer. 
      METHODS: We enrolled 143 patients with a mean age of 63 years, diagnosed with 
      non-small cell lung cancer, in the study. Adenocarcinomas made up 33% of the 
      cases. Patients in stage III or IV of the tumor node metastasis staging system 
      made up 59%. Two polymorphic sites in the promoter region of the HLA-G gene were 
      genotyped (-725C>G>T and -716T>G). RESULTS: All genotyped SNPs were in 
      Hardy-Weinberg equilibrium. No proof of a relationship between genotype -725C>G>T 
      or -716T>G and the risk of lung cancer compared with healthy volunteers from the 
      literature was found. We also found no correlation between the two SNPs and 
      survival time, histological type of cancer, T stage, the presence of remote 
      metastases or performance status according to the Eastern Cooperative Oncology 
      Group (ECOG) scale. The only association we found was genotype -725C>G>T and the 
      degree of lymph node metastases (N stage). CONCLUSIONS: SNPs of the promoter of 
      the HLA-G gene may have an impact on the development of lymph node metastases. In 
      the study we did not prove a relationship between the examined SNPs and the 
      course of the disease because of the small patient groups studied.
FAU - Kowal, Aneta
AU  - Kowal A
AD  - Department of Pulmonology and Lung Cancer, Wroclaw Medical University Wroclaw, 
      Poland.
FAU - Wisniewski, Andrzej
AU  - Wisniewski A
AD  - Laboratory of Immunogenetics, Ludwik Hirszfeld Institute of Immunology and 
      Experimental Therapy, Polish Academy of Sciences Wroclaw, Poland.
FAU - Kusnierczyk, Piotr
AU  - Kusnierczyk P
AD  - Laboratory of Immunogenetics, Ludwik Hirszfeld Institute of Immunology and 
      Experimental Therapy, Polish Academy of Sciences Wroclaw, Poland.
FAU - Jankowska, Renata
AU  - Jankowska R
AD  - Department of Pulmonology and Lung Cancer, Wroclaw Medical University Wroclaw, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20150228
PL  - Singapore
TA  - Thorac Cancer
JT  - Thoracic cancer
JID - 101531441
EIN - Thorac Cancer. 2016 Sep;7(5):623. PMID: 27766773
PMC - PMC4567007
OTO - NOTNLM
OT  - HLA-G
OT  - lung cancer
OT  - promoter
OT  - single nucleotide polymorphism
EDAT- 2015/10/09 06:00
MHDA- 2015/10/09 06:01
PMCR- 2015/09/01
CRDT- 2015/10/08 06:00
PHST- 2014/09/27 00:00 [received]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/10/08 06:00 [entrez]
PHST- 2015/10/09 06:00 [pubmed]
PHST- 2015/10/09 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 10.1111/1759-7714.12232 [doi]
PST - ppublish
SO  - Thorac Cancer. 2015 Sep;6(5):613-9. doi: 10.1111/1759-7714.12232. Epub 2015 Feb 
      28.