PMID- 26446422
OWN - NLM
STAT- MEDLINE
DCOM- 20160901
LR  - 20181113
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 22
IP  - 12
DP  - 2015 Dec
TI  - Vaccination with a Porcine Reproductive and Respiratory Syndrome (PRRS) Modified 
      Live Virus Vaccine Followed by Challenge with PRRS Virus and Porcine Circovirus 
      Type 2 (PCV2) Protects against PRRS but Enhances PCV2 Replication and 
      Pathogenesis Compared to Results for Nonvaccinated Cochallenged Controls.
PG  - 1244-54
LID - 10.1128/CVI.00434-15 [doi]
AB  - Coinfections involving porcine reproductive and respiratory syndrome virus 
      (PRRSV) and porcine circovirus type 2 (PCV2) contribute to a group of disease 
      syndromes known as porcine circovirus-associated disease (PCVAD). Presumably, 
      PRRSV infection enhances PCV2 replication as a result of modulation of host 
      immunity. The purpose of this study was to evaluate PCV2 replication and 
      pathogenesis in pigs vaccinated with a PRRS modified live virus (MLV) vaccine and 
      subsequently challenged with a combination of PRRSV and PCV2. During the early 
      postchallenge period, the number of pigs with PRRSV-associated clinical signs was 
      decreased, and average daily gain (ADG) was increased, in the vaccinated group, 
      demonstrating the protective effect of PRRS vaccination. However, during the 
      later postchallenge period, more pigs in the vaccinated group showed increased 
      PCV2 viremia, decreased ADG, increased PCVAD clinical signs, and increased 
      mortality. In this disease model, the early benefits of PRRSV vaccination were 
      outweighed by the later amplification of PCVAD.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Niederwerder, Megan C
AU  - Niederwerder MC
AD  - Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 
      Kansas State University, Manhattan, Kansas, USA mniederwerder@vet.k-state.edu.
FAU - Bawa, Bhupinder
AU  - Bawa B
AD  - Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 
      Kansas State University, Manhattan, Kansas, USA.
FAU - Serao, Nick V L
AU  - Serao NV
AD  - Department of Animal Science, Iowa State University, Ames, Iowa, USA.
FAU - Trible, Benjamin R
AU  - Trible BR
AD  - Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 
      Kansas State University, Manhattan, Kansas, USA.
FAU - Kerrigan, Maureen A
AU  - Kerrigan MA
AD  - Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 
      Kansas State University, Manhattan, Kansas, USA.
FAU - Lunney, Joan K
AU  - Lunney JK
AD  - U.S. Department of Agriculture, Agricultural Research Service, Beltsville 
      Agricultural Research Center, Beltsville, Maryland, USA.
FAU - Dekkers, Jack C M
AU  - Dekkers JC
AD  - Department of Animal Science, Iowa State University, Ames, Iowa, USA.
FAU - Rowland, Raymond R R
AU  - Rowland RR
AD  - Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 
      Kansas State University, Manhattan, Kansas, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20151007
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Circoviridae Infections/immunology/prevention & control/*veterinary
MH  - Circovirus/immunology/*physiology
MH  - Coinfection/veterinary/virology
MH  - Disease Models, Animal
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & 
      control/virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*immunology
MH  - Sus scrofa
MH  - Swine
MH  - Swine Diseases/immunology/*prevention & control/*virology
MH  - Vaccines, Attenuated/administration & dosage/immunology
MH  - Viral Vaccines/administration & dosage/*immunology
MH  - Viremia/prevention & control/veterinary
MH  - Virus Replication
PMC - PMC4658591
EDAT- 2015/10/09 06:00
MHDA- 2016/09/02 06:00
PMCR- 2016/06/01
CRDT- 2015/10/09 06:00
PHST- 2015/07/30 00:00 [received]
PHST- 2015/10/01 00:00 [accepted]
PHST- 2015/10/09 06:00 [entrez]
PHST- 2015/10/09 06:00 [pubmed]
PHST- 2016/09/02 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - CVI.00434-15 [pii]
AID - 00434-15 [pii]
AID - 10.1128/CVI.00434-15 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2015 Dec;22(12):1244-54. doi: 10.1128/CVI.00434-15. Epub 
      2015 Oct 7.